Abstract
Treatment-related motor fluctuations (MFs) and dyskinesias are considered one of the most important problems in the long-term management of Parkinson's disease (PD). However, only a few studies have focused on their characteristics during advanced and end stages of the disease. We therefore assessed MFs and dyskinesias in a cohort of 61 late/end stage patients with a clinical and pathological diagnosis of PD and investigated the influence of disease- and treatment-related variables on their occurrence. A total of 62.3% of our patients experienced "wearing-off" phenomena, 68.9% "on-off" motor fluctuations and 60.7% dyskinesias at advanced/end stage disease. Age at disease onset and disease duration were significantly associated with dyskinesias. A substantial number of patients experienced spontaneous resolution of their motor complications during the last two years of their disease without treatment modifications. The clinical heterogeneity of treatment-related motor complications in PD points towards a complex mechanism for their etiopathogenesis. Although advanced disease and L-dopa administration are closely tied to their development, other mechanisms involving synaptic aging, altered neuronal plasticity and post-synaptic degeneration may be involved.
| Original language | English |
|---|---|
| Pages (from-to) | 341-345 |
| Number of pages | 5 |
| Journal | Journal of Neural Transmission |
| Volume | 114 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2007 |
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Keywords
- Dyskinesias
- End-stage Parkinson's disease
- Motor fluctuations
- Prevalence
- Therapy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease : A study from a population of brain donors. / Papapetropoulos, S.; Mash, Deborah C.
In: Journal of Neural Transmission, Vol. 114, No. 3, 01.03.2007, p. 341-345.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease
T2 - A study from a population of brain donors
AU - Papapetropoulos, S.
AU - Mash, Deborah C
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Treatment-related motor fluctuations (MFs) and dyskinesias are considered one of the most important problems in the long-term management of Parkinson's disease (PD). However, only a few studies have focused on their characteristics during advanced and end stages of the disease. We therefore assessed MFs and dyskinesias in a cohort of 61 late/end stage patients with a clinical and pathological diagnosis of PD and investigated the influence of disease- and treatment-related variables on their occurrence. A total of 62.3% of our patients experienced "wearing-off" phenomena, 68.9% "on-off" motor fluctuations and 60.7% dyskinesias at advanced/end stage disease. Age at disease onset and disease duration were significantly associated with dyskinesias. A substantial number of patients experienced spontaneous resolution of their motor complications during the last two years of their disease without treatment modifications. The clinical heterogeneity of treatment-related motor complications in PD points towards a complex mechanism for their etiopathogenesis. Although advanced disease and L-dopa administration are closely tied to their development, other mechanisms involving synaptic aging, altered neuronal plasticity and post-synaptic degeneration may be involved.
AB - Treatment-related motor fluctuations (MFs) and dyskinesias are considered one of the most important problems in the long-term management of Parkinson's disease (PD). However, only a few studies have focused on their characteristics during advanced and end stages of the disease. We therefore assessed MFs and dyskinesias in a cohort of 61 late/end stage patients with a clinical and pathological diagnosis of PD and investigated the influence of disease- and treatment-related variables on their occurrence. A total of 62.3% of our patients experienced "wearing-off" phenomena, 68.9% "on-off" motor fluctuations and 60.7% dyskinesias at advanced/end stage disease. Age at disease onset and disease duration were significantly associated with dyskinesias. A substantial number of patients experienced spontaneous resolution of their motor complications during the last two years of their disease without treatment modifications. The clinical heterogeneity of treatment-related motor complications in PD points towards a complex mechanism for their etiopathogenesis. Although advanced disease and L-dopa administration are closely tied to their development, other mechanisms involving synaptic aging, altered neuronal plasticity and post-synaptic degeneration may be involved.
KW - Dyskinesias
KW - End-stage Parkinson's disease
KW - Motor fluctuations
KW - Prevalence
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=33847256408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847256408&partnerID=8YFLogxK
U2 - 10.1007/s00702-006-0603-6
DO - 10.1007/s00702-006-0603-6
M3 - Article
C2 - 17146589
AN - SCOPUS:33847256408
VL - 114
SP - 341
EP - 345
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 3
ER -