Mothers of infants with the acquired immunodeficiency syndrome. Evidence for both symptomatic and asymptomatic carriers

Gwendolyn B Scott, M. A. Fischl, N. Klimas, M. A. Fletcher, Gordon Dickinson, R. S. Levine, W. P. Parks

Research output: Contribution to journalArticle

Abstract

Sixteen mothers of 22 infants with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were followed up for evidence of clinical and immunologic abnormalities. With one exception, all mothers were clinically well at delivery but had evidence of immune dysfunction, with T-cell abnormalities and inverted T4/T8 ratios and/or elevation of serum immunoglobulin levels, particularly of IgG. During a follow-up period that averaged 30 months, AIDS developed in five of the mothers and AIDS-related complex in seven. Twelve subsequent pregnancies in 11 mothers produced four affected infants, suggesting that mothers can be persistently infected. Six mothers were delivered of subsequent infants who remain unaffected. These results suggest that the mothers are the likely source of infection in non-transfusion-associated cases of AIDS or AIDS-related complex in infants, that mothers have persistent immunologic abnormalities, and that they are at increased risk of developing AIDS or AIDS-related complex.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalJournal of the American Medical Association
Volume253
Issue number3
DOIs
StatePublished - Mar 13 1985

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Acquired Immunodeficiency Syndrome
Mothers
CD4-CD8 Ratio
Immunoglobulins
Immunoglobulin G
T-Lymphocytes
Pregnancy
Infection
Serum

ASJC Scopus subject areas

  • Medicine(all)

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Mothers of infants with the acquired immunodeficiency syndrome. Evidence for both symptomatic and asymptomatic carriers. / Scott, Gwendolyn B; Fischl, M. A.; Klimas, N.; Fletcher, M. A.; Dickinson, Gordon; Levine, R. S.; Parks, W. P.

In: Journal of the American Medical Association, Vol. 253, No. 3, 13.03.1985, p. 363-366.

Research output: Contribution to journalArticle

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