Abstract
The intravesical administration of mitomycin C to normal and N-[4-(5-nitro-2-furyl)-2-thiozolyl]formamide-induced bladder tumor-carrying mice at initial concentrations of 2 and 5 mg/ml for 2 hr resulted in marked morphological effects including cytoplasmic and nuclear abnormalities and disruption of surface architecture. Tumor cells and normal urothelial cells were sensitive to the effects of mitomycin C. These effects were limited to epithelial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 261-267 |
| Number of pages | 7 |
| Journal | Cancer Research |
| Volume | 40 |
| Issue number | 2 |
| State | Published - Jan 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder neoplasms. / Daskal, Y.; Soloway, M. S.; DeFuria, M. D.; Crooke, S. T.
In: Cancer Research, Vol. 40, No. 2, 01.01.1980, p. 261-267.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder neoplasms
AU - Daskal, Y.
AU - Soloway, M. S.
AU - DeFuria, M. D.
AU - Crooke, S. T.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The intravesical administration of mitomycin C to normal and N-[4-(5-nitro-2-furyl)-2-thiozolyl]formamide-induced bladder tumor-carrying mice at initial concentrations of 2 and 5 mg/ml for 2 hr resulted in marked morphological effects including cytoplasmic and nuclear abnormalities and disruption of surface architecture. Tumor cells and normal urothelial cells were sensitive to the effects of mitomycin C. These effects were limited to epithelial cells.
AB - The intravesical administration of mitomycin C to normal and N-[4-(5-nitro-2-furyl)-2-thiozolyl]formamide-induced bladder tumor-carrying mice at initial concentrations of 2 and 5 mg/ml for 2 hr resulted in marked morphological effects including cytoplasmic and nuclear abnormalities and disruption of surface architecture. Tumor cells and normal urothelial cells were sensitive to the effects of mitomycin C. These effects were limited to epithelial cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018832426&partnerID=8YFLogxK
M3 - Article
C2 - 7356509
AN - SCOPUS:0018832426
VL - 40
SP - 261
EP - 267
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 2
ER -