Morphological effects of mitomycin c administered intravesically to normal mice and mice with af-[4-(5-nitro-2-furyl)-2-thiazolyl]- formamide-induced bladder neoplasms

Yerach Daskal, Mark S. Soloway, M. Dianne DeFuria, Stanley T. Crooke

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The intravesical administration of mitomycin C to normal and N-[4-(5-nitro-2-furyl)-2-thiozolyl]formamide-induced bladder tumor-carrying mice at initial concentrations of 2 and 5 mg/ml for 2 hr resulted in marked morphological effects including cytoplasmic and nuclear abnormalities and disruption of surface architecture. Tumor cells and normal urothelial cells were sensitive to the effects of mitomycin C. These effects were limited to epithelial cells.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalCancer Research
Volume40
Issue number2
StatePublished - Feb 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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