Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder neoplasms

Y. Daskal, M. S. Soloway, M. D. DeFuria, S. T. Crooke

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The intravesical administration of mitomycin C to normal and N-[4-(5-nitro-2-furyl)-2-thiozolyl]formamide-induced bladder tumor-carrying mice at initial concentrations of 2 and 5 mg/ml for 2 hr resulted in marked morphological effects including cytoplasmic and nuclear abnormalities and disruption of surface architecture. Tumor cells and normal urothelial cells were sensitive to the effects of mitomycin C. These effects were limited to epithelial cells.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalCancer Research
Volume40
Issue number2
StatePublished - Jan 1 1980
Externally publishedYes

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Mitomycin
Urinary Bladder Neoplasms
Intravesical Administration
Epithelial Cells
Neoplasms
formamide

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder neoplasms. / Daskal, Y.; Soloway, M. S.; DeFuria, M. D.; Crooke, S. T.

In: Cancer Research, Vol. 40, No. 2, 01.01.1980, p. 261-267.

Research output: Contribution to journalArticle

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