Morphological basis for the cytolytic effect of vinblastine and vincristine on cultured human leukemic lymphoblasts

A. Krishan, E. Frei

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalCancer Research
Volume35
Issue number3
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Vinblastine
Vincristine
Cytoplasm
Thrombocytosis
Cell Shape
Bleomycin
Vacuoles
Doxorubicin
Suspensions
Fibroblasts
Membranes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Morphological basis for the cytolytic effect of vinblastine and vincristine on cultured human leukemic lymphoblasts. / Krishan, A.; Frei, E.

In: Cancer Research, Vol. 35, No. 3, 01.12.1975, p. 497-501.

Research output: Contribution to journalArticle

@article{6aa19d0bff1646c18b8438192bde39d0,
title = "Morphological basis for the cytolytic effect of vinblastine and vincristine on cultured human leukemic lymphoblasts",
abstract = "Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.",
author = "A. Krishan and E. Frei",
year = "1975",
month = "12",
day = "1",
language = "English",
volume = "35",
pages = "497--501",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "3",

}

TY - JOUR

T1 - Morphological basis for the cytolytic effect of vinblastine and vincristine on cultured human leukemic lymphoblasts

AU - Krishan, A.

AU - Frei, E.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.

AB - Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0016636565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016636565&partnerID=8YFLogxK

M3 - Article

C2 - 46777

AN - SCOPUS:0016636565

VL - 35

SP - 497

EP - 501

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 3

ER -