Abstract
Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 497-501 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 35 |
| Issue number | 3 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Morphological basis for the cytolytic effect of vinblastine and vincristine on cultured human leukemic lymphoblasts. / Krishan, A.; Frei, E.
In: Cancer Research, Vol. 35, No. 3, 01.12.1975, p. 497-501.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Morphological basis for the cytolytic effect of vinblastine and vincristine on cultured human leukemic lymphoblasts
AU - Krishan, A.
AU - Frei, E.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.
AB - Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacuoles. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine and vincristine induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016636565&partnerID=8YFLogxK
M3 - Article
C2 - 46777
AN - SCOPUS:0016636565
VL - 35
SP - 497
EP - 501
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 3
ER -