Morphological aspects of proteoglycans in systemic scleroderma

A. Montagnani, L. Baratta, A. Tosti

Research output: Contribution to journalArticlepeer-review


The proteoglycans and their relationship with collagen fibrils have been studied by electron microscope. The specimens were obtained from the dermis of 9 women affected by systemic scleroderma. The results demonstrate that in systemic scleroderma there is a considerable increase in the amount of proteoglycans connected to the collagen fibrils, as well as an alteration in their distribution. However, in the control groups, they are small isolated round bodies on the surface of the collagen fibrils. In scleroderma they are round bodies, clumped in masses or in long chains, arranged as a network which enmeshes collagen fibrils or frequently are located some distance from the collagen fibrils. These phenomena are demonstrated in both affected and perilesional areas; thereby confirming that even limited lesions are the expression of a diffuse pathological process.

Original languageEnglish (US)
Pages (from-to)171-185
Number of pages15
JournalAnnali Italiani di Dermatologia Clinica e Sperimentale
Issue number3
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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