Morphological approach to hair disorders

Rodney Sinclair, Damian Jolley, Rica Mallari, Jill Magee, Antonella Tosti, Bianca Maria Piracinni, C. Vincenzi, Rudolf Happle, Juan Ferrando, Ramon Grimalt, Leroy Thérèse, Dominique Van Neste, Abraham Zlotogorski, Angela M. Christiano, David Whiting

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The Workshop on the morphological approach to hair disorders brought together a group of clinicians involved in hair biology research. Six speakers spoke on a range of topics that can be grouped broadly into a central theme. It summarizes the evolution of medical research. The section by Tosti and coworkers describes a patient with a new unique syndrome. The section by Ferrando and colleagues provides a framework in which patients with rare hair disorders can be classified. The section by Whiting tries to define the normal anatomy of the hair follicle and both horizontal and vertical sections. It is only when normal anatomy has been absolutely defined that pathological deviations can be recognized. The section by Sinclair and coworkers attempts to estimate the reliability of histological diagnosis so that its true value of pathology can be recognized. The section by Zlotogorski and coworkers shows how accurate clinical and histological definition of disease acts as the cornerstone for gene discovery techniques. Once a causative mutation is found and a gene product identified, then the biological consequences of the altered protein product can be studied and the impact of the abnormal molecular function on hair biology can be understood. It is hoped that improved understanding of hair disease will then lead to useful therapeutic interventions. The final section by Leroy and Van Neste highlights the difficulties of evaluating therapeutic interventions in hair loss disease and proposes a new technique.

Original languageEnglish
Pages (from-to)56-64
Number of pages9
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume8
Issue number1
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Fingerprint

Hair
Hair Diseases
Anatomy
Hair Follicle
Alopecia
Genetic Association Studies
Biomedical Research
Pathology
Education
Mutation
Therapeutics
Research
Genes
Proteins

Keywords

  • Blaschko
  • Papular atrichia
  • Scalp biopsy histology

ASJC Scopus subject areas

  • Dermatology

Cite this

Sinclair, R., Jolley, D., Mallari, R., Magee, J., Tosti, A., Piracinni, B. M., ... Whiting, D. (2003). Morphological approach to hair disorders. Journal of Investigative Dermatology Symposium Proceedings, 8(1), 56-64. https://doi.org/10.1046/j.1523-1747.2003.12172.x

Morphological approach to hair disorders. / Sinclair, Rodney; Jolley, Damian; Mallari, Rica; Magee, Jill; Tosti, Antonella; Piracinni, Bianca Maria; Vincenzi, C.; Happle, Rudolf; Ferrando, Juan; Grimalt, Ramon; Thérèse, Leroy; Van Neste, Dominique; Zlotogorski, Abraham; Christiano, Angela M.; Whiting, David.

In: Journal of Investigative Dermatology Symposium Proceedings, Vol. 8, No. 1, 01.06.2003, p. 56-64.

Research output: Contribution to journalArticle

Sinclair, R, Jolley, D, Mallari, R, Magee, J, Tosti, A, Piracinni, BM, Vincenzi, C, Happle, R, Ferrando, J, Grimalt, R, Thérèse, L, Van Neste, D, Zlotogorski, A, Christiano, AM & Whiting, D 2003, 'Morphological approach to hair disorders', Journal of Investigative Dermatology Symposium Proceedings, vol. 8, no. 1, pp. 56-64. https://doi.org/10.1046/j.1523-1747.2003.12172.x
Sinclair, Rodney ; Jolley, Damian ; Mallari, Rica ; Magee, Jill ; Tosti, Antonella ; Piracinni, Bianca Maria ; Vincenzi, C. ; Happle, Rudolf ; Ferrando, Juan ; Grimalt, Ramon ; Thérèse, Leroy ; Van Neste, Dominique ; Zlotogorski, Abraham ; Christiano, Angela M. ; Whiting, David. / Morphological approach to hair disorders. In: Journal of Investigative Dermatology Symposium Proceedings. 2003 ; Vol. 8, No. 1. pp. 56-64.
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