Morphologic effects of thio-TEPA on mouse urothelium

W. M. Murphy; M. S. Soloway; C. J. Lin

Morphologic effects of thio-TEPA on mouse urothelium

W. M. Murphy, M. S. Soloway, C. J. Lin

Urology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.

Original language	English (US)
Pages (from-to)	701-704
Number of pages	4
Journal	Acta Cytologica
Volume	21
Issue number	5
State	Published - Dec 1 1977

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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title = "Morphologic effects of thio-TEPA on mouse urothelium",

abstract = "The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.",

author = "Murphy, {W. M.} and Soloway, {M. S.} and Lin, {C. J.}",

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AU - Murphy, W. M.

AU - Soloway, M. S.

AU - Lin, C. J.

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N2 - The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.

AB - The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.

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