The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Dec 1 1977|
ASJC Scopus subject areas
- Pathology and Forensic Medicine