Abstract
The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 701-704 |
| Number of pages | 4 |
| Journal | Acta Cytologica |
| Volume | 21 |
| Issue number | 5 |
| State | Published - Dec 1 1977 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology