Morphologic effects of thio-TEPA on mouse urothelium

W. M. Murphy, M. S. Soloway, C. J. Lin

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The urothelial changes induced by intravesical instillation of thio-TEPA into experimental animals were studied by cytologic, light microscopic, and electron microscopic techniques. Cells and tissue from treated and untreated groups were compared using a total of 54 discriminators. There were few consistent differences. Cells with marked nuclear atypia were not identified. The results indicate that thio-TEPA has little effect on non-diseased bladders. The atypical cells occasionally present in specimens from thio-TEPA treated bladders apparently do not emanate from normal urothelium.

Original languageEnglish (US)
Pages (from-to)701-704
Number of pages4
JournalActa Cytologica
Issue number5
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Murphy, W. M., Soloway, M. S., & Lin, C. J. (1977). Morphologic effects of thio-TEPA on mouse urothelium. Acta Cytologica, 21(5), 701-704.