Morphologic changes in the inner ear of Chinchilla laniger after middle ear administration of gentamicin in a sustained-release vehicle

Michael E. Hoffer, Ben J. Balough, Richard D. Kopke, Jenifer Henderson, Michael Decicco, Derin C. Wester, Michael J. O'Leary, Carey Balaban

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The use of transtympanic gentamicin has become a popular method of treating Meniere's disease; nevertheless, many questions still remain regarding this therapy. Until investigators can control the exact amount of medicine that is administered to the ear and have an understanding of the kinetics of gentamicin, therapy will continue to rely on empirical data. Previously we described the use of a fibrin-based sustained-release vehicle impregnated with gentamicin in the middle ears of chinchillas. With this model a kinetics curve of gentamicin was defined. The inner ears of these animals were submitted for immunohistochemical and histologic analysis. We discuss the ultrastructural changes seen and correlate this to our kinetics data. We also examine measurement of hair cell damage with heat shock protein levels. By better understanding the actions of gentamicin in this animal model, we hope to facilitate safer use of intratympanic medicines in our patient population.

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume120
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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