Mood disorder and epilepsy

A neurobiologic perspective of their relationship

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Mood disorders are the most frequent psychiatric comorbidity in epilepsy, and in particular in temporal lobe epilepsy. For a long time, depressive disorders were considered to be the expression of a reactive process to the obstacles of a life with epilepsy. Data obtained in the last two decades, however, have demonstrated biochemical, neuropathological, and neurophysiology changes mediating the development of mood disorders, which in fact can be tested in animal models. Furthermore, there is also evidence that mood disorders and epilepsy have a complex relationship which is bidirectional; that is, not only are patients with epilepsy at greater risk of developing depression, but patients with depression have a higher risk of developing epilepsy. Such a relationship can only be explained by the existence of common pathogenic mechanisms that are operant in both conditions. These include changes in neurotransmitters, such as serotonin, norepinephrine, glutamate, and γ-aminobutyric acid. Such a bidirectional relationship also appears to have important clinical consequences. Indeed, patients with a history of mood disorders are twice as likely to develop pharmacoresistant epilepsy as those without such a history. These data are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalDialogues in Clinical Neuroscience
Volume10
Issue number1
StatePublished - 2008
Externally publishedYes

Fingerprint

Mood Disorders
Epilepsy
Depression
Aminobutyrates
Neurophysiology
Temporal Lobe Epilepsy
Depressive Disorder
Neurotransmitter Agents
Psychiatry
Comorbidity
Glutamic Acid
Serotonin
Norepinephrine
Animal Models
History

Keywords

  • Genetically epilepsy-prone rat
  • Hippocampal atrophy
  • Major depressive disorder
  • Norepinephrine
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Mood disorder and epilepsy : A neurobiologic perspective of their relationship. / Kanner, Andres M.

In: Dialogues in Clinical Neuroscience, Vol. 10, No. 1, 2008, p. 39-45.

Research output: Contribution to journalArticle

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