Monte Carlo-based dosimetry of head-and-neck patients treated with SIB-IMRT

Nirmal Sakthi, Paul Keall, Ivaylo B Mihaylov, Qiuwen Wu, Yan Wu, Jeffrey F. Williamson, Rupert Schmidt-Ullrich, Jeffrey V. Siebers

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: To evaluate the accuracy of previously reported superposition/convolution (SC) dosimetric results by comparing with Monte Carlo (MC) dose calculations for head-and-neck intensity-modulated radiation therapy (IMRT) patients treated with the simultaneous integrated boost technique. Methods and Materials: Thirty-one plans from 24 patients previously treated on a phase I/II head-and-neck squamous cell carcinoma simultaneous integrated boost IMRT protocol were used. Clinical dose distributions, computed with an SC algorithm, were recomputed using an EGS4-based MC algorithm. Phantom-based dosimetry quantified the fluence prediction accuracy of each algorithm. Dose-volume indices were used to compare patient dose distributions. Results and Discussion: The MC algorithm predicts flat-phantom measurements better than the SC algorithm. Average patient dose indices agreed within 2.5% of the local dose for targets; 5.0% for parotids; and 1.9% for cord and brainstem. However, only 1 of 31 plans agreed within 3% for all indices; 4 of 31 agreed within 5%. In terms of the prescription dose, 4 of 31 plans agreed within 3% for all indices, whereas 28 of 31 agreed within 5%. Conclusions: Average SC-computed doses agreed with MC results in the patient geometry; however deviations >5% were common. The fluence modulation prediction is likely the major source of the dose discrepancy. The observed dose deviations can impact dose escalation protocols, because they would result in shifting patients to higher dose levels.

Original languageEnglish (US)
Pages (from-to)968-977
Number of pages10
JournalInternational Journal of Radiation Oncology Biology Physics
Volume64
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

dosimeters
radiation therapy
Neck
Radiotherapy
Head
dosage
convolution integrals
Hospital Distribution Systems
acceleration (physics)
Brain Stem
Prescriptions
fluence
deviation
predictions
cancer
modulation

Keywords

  • Dynamic multileaf collimators
  • Head-and-neck cancer
  • IMRT
  • Monte Carlo
  • Radiotherapy
  • Simultaneous integrated boost

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Monte Carlo-based dosimetry of head-and-neck patients treated with SIB-IMRT. / Sakthi, Nirmal; Keall, Paul; Mihaylov, Ivaylo B; Wu, Qiuwen; Wu, Yan; Williamson, Jeffrey F.; Schmidt-Ullrich, Rupert; Siebers, Jeffrey V.

In: International Journal of Radiation Oncology Biology Physics, Vol. 64, No. 3, 01.03.2006, p. 968-977.

Research output: Contribution to journalArticle

Sakthi, Nirmal ; Keall, Paul ; Mihaylov, Ivaylo B ; Wu, Qiuwen ; Wu, Yan ; Williamson, Jeffrey F. ; Schmidt-Ullrich, Rupert ; Siebers, Jeffrey V. / Monte Carlo-based dosimetry of head-and-neck patients treated with SIB-IMRT. In: International Journal of Radiation Oncology Biology Physics. 2006 ; Vol. 64, No. 3. pp. 968-977.
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