Monosodium L glutamate induced convulsions: temporary alteration in blood brain barrier permeability to plasma proteins

Charles Nemeroff, F. D. Crisley

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

Monosodium L glutamate (MSG), a commonly used food additive, induces convulsive disorders in rats. A reversible change in the cerebrovascular permeability of plasma proteins occurs during convulsions induced by the intraperitoneal administration of 4.0 g/kg of MSG to the neonatal rat. During MSG induced seizures, but not before or after, trypan blue dye enters into the brain tissues, whereas no dye penetration occurs in control rats receiving saline. The frequency of the incidence of MSG induced convulsions is inversely proportional to the age of the animal. It decreases with the age of the rat. By 42 days of age no substantial seizure activity or dye penetration into the brain tissue occurs in MSG treated rats. Histological examination indicates that seizure activity is not correlated with characteristic periventricular arcuate area lesions known to be induced in neonates by parenteral MSG administration. No hypothalamic damage was observed in MSG treated rats older than 10 days of age.

Original languageEnglish
Title of host publicationENVIRONM.PHYSIOL.BIOCHEM.
Pages389-395
Number of pages7
Volume5
Edition6
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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