Monophasic synovial sarcoma of the liver

Amitabh Srivastava, Petur G. Nielsen, Paola Dal Cin, Andrew Rosenberg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report a hepatic monophasic synovial sarcoma in a 60-year-old woman who presented with right upper quadrant pain subsequent to an intrahepatic bleed from a highly vascular tumor mass. Imaging studies showed a dominant tumor mass in the right hepatic lobe with multiple satellite nodules. A detailed physical examination and radiologic workup failed to reveal a primary tumor elsewhere. A right partial hepatectomy was performed with a preoperative differential diagnosis of angiosarcoma versus hepatocellular carcinoma. The morphologic, immunophenotypic, and cytogenetic findings (t(X;18)(p11.2;q11.2)) were consistent with a monophasic synovial sarcoma. Postoperative clinical evaluation of the extremities and a positron emission tomographic scan performed 4 weeks after surgery showed no evidence of recurrent or metastatic disease. The patient was started on an aggressive 4-drug chemotherapy regimen, but died 3 months thereafter from widespread metastatic disease. No autopsy was performed. The presence of multiple lesions in the liver certainly suggests the possibility of metastatic disease. It would, however, be very unusual for a synovial sarcoma to present as an occult primary, and the negative radiologic workup 1 month after the partial hepatectomy also argues against this possibility. The clinical presentation, radiographic findings, and subsequent course in this patient was therefore most consistent with a primary monophasic synovial sarcoma of the liver.

Original languageEnglish
Pages (from-to)1047-1049
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume129
Issue number8
StatePublished - Aug 1 2005
Externally publishedYes

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Synovial Sarcoma
Liver
Hepatectomy
Neoplasms
Hemangiosarcoma
Cytogenetics
Physical Examination
Blood Vessels
Hepatocellular Carcinoma
Autopsy
Differential Diagnosis
Extremities
Electrons
Drug Therapy
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Srivastava, A., Nielsen, P. G., Cin, P. D., & Rosenberg, A. (2005). Monophasic synovial sarcoma of the liver. Archives of Pathology and Laboratory Medicine, 129(8), 1047-1049.

Monophasic synovial sarcoma of the liver. / Srivastava, Amitabh; Nielsen, Petur G.; Cin, Paola Dal; Rosenberg, Andrew.

In: Archives of Pathology and Laboratory Medicine, Vol. 129, No. 8, 01.08.2005, p. 1047-1049.

Research output: Contribution to journalArticle

Srivastava, A, Nielsen, PG, Cin, PD & Rosenberg, A 2005, 'Monophasic synovial sarcoma of the liver', Archives of Pathology and Laboratory Medicine, vol. 129, no. 8, pp. 1047-1049.
Srivastava A, Nielsen PG, Cin PD, Rosenberg A. Monophasic synovial sarcoma of the liver. Archives of Pathology and Laboratory Medicine. 2005 Aug 1;129(8):1047-1049.
Srivastava, Amitabh ; Nielsen, Petur G. ; Cin, Paola Dal ; Rosenberg, Andrew. / Monophasic synovial sarcoma of the liver. In: Archives of Pathology and Laboratory Medicine. 2005 ; Vol. 129, No. 8. pp. 1047-1049.
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