Monocyte phagocytic activity in sickle cell disease

E. Mendoza, N. Gutgsell, J. D. Temple, P. Issitt

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The phagocytic activity of peripheral blood monocytes from sickle cell disease patients and normal controls was studied using a monocyte monolayer assay. Phagocytosis of antibody-coated red cells by monocytes from patients in stable condition and in normal controls did not differ significantly (7.1 ± 1.5 vs. 5.3 ± 0.9%). However, monocytes from sickle cell disease patients during vasoocclusive crises demonstrated increased phagocytic activity compared to the normal controls (11.0 ± 2.7 vs. 5.3 ±0.9%, P < 0.025). Numerous defects in immune response have been described in association with sickle cell disease. However, monocyte phagocytic activity is not deficient and is not a factor in the predisposition to infections.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalActa Haematologica
Volume85
Issue number4
DOIs
StatePublished - Jan 1 1991

Keywords

  • monocyte monolayer assay
  • monocytes
  • sickle cell disease

ASJC Scopus subject areas

  • Hematology

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    Mendoza, E., Gutgsell, N., Temple, J. D., & Issitt, P. (1991). Monocyte phagocytic activity in sickle cell disease. Acta Haematologica, 85(4), 199-201. https://doi.org/10.1159/000204892