Monoclonal gammopathy of undetermined significance and risk of infections: A population-based study

Sigurdur Y. Kristinsson, Min Tang, Ruth M. Pfeiffer, Magnus Björkholm, Lynn R. Goldin, Cecilie Blimark, Ulf Henrik Mellqvist, Anders Wahlin, Ingemar Turesson, Ola Landgren

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

No comprehensive evaluation has been made to assess the risk of viral and bacterial infections among patients with monoclonal gammopathy of undetermined significance. Using population- based data from Sweden, we estimated risk of infections among 5,326 monoclonal gammopathy of undetermined significance patients compared to 20,161 matched controls. Patients with monoclonal gammopathy of undetermined significance had a 2-fold increased risk (P<0.05) of developing any infection at 5- and 10-year follow up. More specifically, patients with monoclonal gammopathy of undetermined significance had an increased risk (P<0.05) of bacterial (pneumonia, osteomyelitis, septicemia, pyelonephritis, cellulitis, endocarditis, and meningitis), and viral (influenza and herpes zoster) infections. Patients with monoclonal gammopathy of undetermined significance with M-protein concentrations over 2.5 g/dL at diagnosis had highest risks of infections. However, the risk was also increased (P<0.05) among those with concentrations below 0.5 g/dL. Patients with monoclonal gammopathy of undetermined significance who developed infections had no excess risk of developing multiple myeloma, Waldenström macroglobulinemia or related malignancy. Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications.

Original languageEnglish (US)
Pages (from-to)854-858
Number of pages5
JournalHaematologica
Volume97
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Bacteria
  • Infections
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma
  • Virus

ASJC Scopus subject areas

  • Hematology

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