Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas

Mehrdad Nadji, Shinobu Matsuo, Parvin Ganjei, Jocelyn Ziegels-Weissman, Neal S. Penneys

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.

Original languageEnglish (US)
Pages (from-to)68-71
Number of pages4
JournalActa Haematologica
Volume79
Issue number2
DOIs
StatePublished - Jan 1 1988

Keywords

  • Erythropoietin
  • Hepatocellular carcinoma
  • Monoclonal antibodies
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Hematology

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