Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas

Mehrdad Nadji; Shinobu Matsuo; Parvin Ganjei; Jocelyn Ziegels-Weissman; Neal S. Penneys

doi:10.1159/000205722

Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas

Mehrdad Nadji, Shinobu Matsuo, Parvin Ganjei, Jocelyn Ziegels-Weissman, Neal S. Penneys

Pathology

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5 Scopus citations

Abstract

We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.

Original language	English (US)
Pages (from-to)	68-71
Number of pages	4
Journal	Acta Haematologica
Volume	79
Issue number	2
DOIs	https://doi.org/10.1159/000205722
State	Published - 1988

Keywords

Erythropoietin
Hepatocellular carcinoma
Monoclonal antibodies
Renal cell carcinoma

ASJC Scopus subject areas

Hematology

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10.1159/000205722

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title = "Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas",

abstract = "We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.",

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T1 - Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas

AU - Nadji, Mehrdad

AU - Matsuo, Shinobu

AU - Ganjei, Parvin

AU - Ziegels-Weissman, Jocelyn

AU - Penneys, Neal S.

PY - 1988

Y1 - 1988

N2 - We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.

AB - We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.

KW - Erythropoietin

KW - Hepatocellular carcinoma

KW - Monoclonal antibodies

KW - Renal cell carcinoma

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Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas

Abstract

Keywords

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