TY - JOUR
T1 - Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas
AU - Nadji, Mehrdad
AU - Matsuo, Shinobu
AU - Ganjei, Parvin
AU - Ziegels-Weissman, Jocelyn
AU - Penneys, Neal S.
PY - 1988
Y1 - 1988
N2 - We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.
AB - We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.
KW - Erythropoietin
KW - Hepatocellular carcinoma
KW - Monoclonal antibodies
KW - Renal cell carcinoma
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U2 - 10.1159/000205722
DO - 10.1159/000205722
M3 - Article
C2 - 2829493
AN - SCOPUS:0023818193
VL - 79
SP - 68
EP - 71
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 2
ER -