Abstract
We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 68-71 |
| Number of pages | 4 |
| Journal | Acta Haematologica |
| Volume | 79 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1988 |
Keywords
- Erythropoietin
- Hepatocellular carcinoma
- Monoclonal antibodies
- Renal cell carcinoma
ASJC Scopus subject areas
- Hematology
Fingerprint Dive into the research topics of 'Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas'. Together they form a unique fingerprint.
Cite this
Nadji, M., Matsuo, S., Ganjei, P., Ziegels-Weissman, J., & Penneys, N. S. (1988). Monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas. Acta Haematologica, 79(2), 68-71. https://doi.org/10.1159/000205722