Abstract
Cellular resistance to a broad spectrum of natural products used as antitumor drugs is believed to be a major cause for the failure of chemotherapy. Flow cytometry has been used for monitoring the expression of drug resistance markers, determining accumulation of fluorescent drugs, and for screening of drugs that enhance chemosensitivity by blocking efflux and enhancing drug retention. This article reviews recent developments in our understanding of the multiple drug resistance phenotype and the use of flow cytometry for the study of drug efflux and its modulation in human tumor cells.
| Original language | English |
|---|---|
| Pages (from-to) | 357-372 |
| Number of pages | 16 |
| Journal | Hematology/Oncology Clinics of North America |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 2 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
Monitoring of cellular resistance to cancer chemotherapy. / Krishan, Awtar; Arya, Poonam.
In: Hematology/Oncology Clinics of North America, Vol. 16, No. 2, 02.07.2002, p. 357-372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monitoring of cellular resistance to cancer chemotherapy
AU - Krishan, Awtar
AU - Arya, Poonam
PY - 2002/7/2
Y1 - 2002/7/2
N2 - Cellular resistance to a broad spectrum of natural products used as antitumor drugs is believed to be a major cause for the failure of chemotherapy. Flow cytometry has been used for monitoring the expression of drug resistance markers, determining accumulation of fluorescent drugs, and for screening of drugs that enhance chemosensitivity by blocking efflux and enhancing drug retention. This article reviews recent developments in our understanding of the multiple drug resistance phenotype and the use of flow cytometry for the study of drug efflux and its modulation in human tumor cells.
AB - Cellular resistance to a broad spectrum of natural products used as antitumor drugs is believed to be a major cause for the failure of chemotherapy. Flow cytometry has been used for monitoring the expression of drug resistance markers, determining accumulation of fluorescent drugs, and for screening of drugs that enhance chemosensitivity by blocking efflux and enhancing drug retention. This article reviews recent developments in our understanding of the multiple drug resistance phenotype and the use of flow cytometry for the study of drug efflux and its modulation in human tumor cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036080406&partnerID=8YFLogxK
U2 - 10.1016/S0889-8588(01)00016-8
DO - 10.1016/S0889-8588(01)00016-8
M3 - Article
C2 - 12094476
AN - SCOPUS:0036080406
VL - 16
SP - 357
EP - 372
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 2
ER -