Monitoring levels of preservative sensitivity in Europe: A 10-year overview (1991-2000)

J. D. Wilkinson, S. Shaw, K. E. Andersen, F. M. Brandao, D. P. Bruynzeel, M. Bruze, J. M.G. Camarasa, T. L. Diepgen, G. Ducombs, P. J. Frosch, A. Goossens, J. M. Lachappelle, A. Lahti, T. Menné, S. Seidenari, A. Tosti, J. E. Wahlberg

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.

Original languageEnglish (US)
Pages (from-to)207-210
Number of pages4
JournalContact dermatitis
Issue number4
StatePublished - 2002
Externally publishedYes


  • 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one
  • Diazolidinyl urea
  • Formaldehyde
  • Imidazolidinyl urea
  • Methyldibromoglutaronitrile
  • Parabens
  • Patch test sensitization
  • Preservatives
  • Quaternium-15

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology


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