Monitoring and treatment of minimal residual cancer of the prostate.

G. Mathé, A. V. Schally, A. M. Comaru-Schally, R. Y. Mauvernay, M. L. Vovan, D. Machover, J. L. Misset, B. Court, P. Bouchard, J. Duchier

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Abstract

In manifest prostatic carcinoma, partial and complete remissions are obtained in 14-44% of patients as judged by different sets of criteria, but in up to 61% as judged by a decrease in prostatic acid phosphatase. Moreover, this decrease is poorly correlated to that of prostatic size. Prostatic acid phosphatase is therefore considered to be a relatively non-specific tumor marker. A complete remission, i.e. a stage of minimal residual disease, is obtained in about 25% of the patients. Continued endocrine treatment involves the risk of a flare-up of the disease, which is probably small. Additionally, in minimal residual disease, prolonged maintenance treatment requires minimization of side effects. D-Trp-6-LH-RH appears to lead to less gynecomastia and thromboembolism than some other forms of adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)65-74
Number of pages10
JournalBulletin de la Societe des Sciences Medicales du Grand-Duche de Luxembourg
Volume126
Issue number1
StatePublished - Mar 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mathé, G., Schally, A. V., Comaru-Schally, A. M., Mauvernay, R. Y., Vovan, M. L., Machover, D., Misset, J. L., Court, B., Bouchard, P., & Duchier, J. (1989). Monitoring and treatment of minimal residual cancer of the prostate. Bulletin de la Societe des Sciences Medicales du Grand-Duche de Luxembourg, 126(1), 65-74.