Molecular targets in therapy for human soft-tissue and bone sarcomas

Dejka M. Steinert, L. Johnetta Blakely, Jason Salganick, Jonathan C. Trent

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Sarcomas represent a heterogeneous group of tumors with different natural histories and therapeutic approaches. Recent discoveries have identified molecular alterations in the pathogenesis of these tumors that lead to distinct effects on sarcoma cell biology. These tumor cell characteristics include independence from growth factors, evasion of apoptosis, and maintenance of genomic integrity. Inhibition of these molecular alterations represents a therapeutic opportunity to reverse the biologic basis of tumor formation in soft-tissue sarcomas and bone tumors.

Original languageEnglish (US)
Pages (from-to)295-303
Number of pages9
JournalCurrent oncology reports
Volume5
Issue number4
DOIs
StatePublished - Jul 2003

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ASJC Scopus subject areas

  • Oncology

Cite this

Steinert, D. M., Blakely, L. J., Salganick, J., & Trent, J. C. (2003). Molecular targets in therapy for human soft-tissue and bone sarcomas. Current oncology reports, 5(4), 295-303. https://doi.org/10.1007/s11912-003-0069-8