Molecular targets in therapy for human soft-tissue and bone sarcomas

Dejka M. Steinert, L. Johnetta Blakely, Jason Salganick, Jonathan Trent

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sarcomas represent a heterogeneous group of tumors with different natural histories and therapeutic approaches. Recent discoveries have identified molecular alterations in the pathogenesis of these tumors that lead to distinct effects on sarcoma cell biology. These tumor cell characteristics include independence from growth factors, evasion of apoptosis, and maintenance of genomic integrity. Inhibition of these molecular alterations represents a therapeutic opportunity to reverse the biologic basis of tumor formation in soft-tissue sarcomas and bone tumors.

Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalCurrent Oncology Reports
Volume5
Issue number4
StatePublished - Jul 1 2003
Externally publishedYes

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Sarcoma
Bone and Bones
Neoplasms
Therapeutics
Natural History
Cell Biology
Intercellular Signaling Peptides and Proteins
Maintenance
Apoptosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Steinert, D. M., Blakely, L. J., Salganick, J., & Trent, J. (2003). Molecular targets in therapy for human soft-tissue and bone sarcomas. Current Oncology Reports, 5(4), 295-303.

Molecular targets in therapy for human soft-tissue and bone sarcomas. / Steinert, Dejka M.; Blakely, L. Johnetta; Salganick, Jason; Trent, Jonathan.

In: Current Oncology Reports, Vol. 5, No. 4, 01.07.2003, p. 295-303.

Research output: Contribution to journalArticle

Steinert, DM, Blakely, LJ, Salganick, J & Trent, J 2003, 'Molecular targets in therapy for human soft-tissue and bone sarcomas', Current Oncology Reports, vol. 5, no. 4, pp. 295-303.
Steinert DM, Blakely LJ, Salganick J, Trent J. Molecular targets in therapy for human soft-tissue and bone sarcomas. Current Oncology Reports. 2003 Jul 1;5(4):295-303.
Steinert, Dejka M. ; Blakely, L. Johnetta ; Salganick, Jason ; Trent, Jonathan. / Molecular targets in therapy for human soft-tissue and bone sarcomas. In: Current Oncology Reports. 2003 ; Vol. 5, No. 4. pp. 295-303.
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