Molecular targets for steroids in airway vascular smooth muscle

Gabor Horvath, A. Wanner

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The actions of norepinephrine (NE) released from airway sympathetic nerves are partially terminated by the extraneuronal catecholamine uptake. Because various steroid hormones inhibit extraneuronal uptake, it could be responsible for the airway vasoconstriction caused by inhaled glucocorticosteroids (GSs) in vivo. Using bronchial arteries obtained from donor lungs rejected for transplantation, we showed that a plasma membrane-associated transporter is responsible for NE uptake by airway vascular smooth muscle. We identified this transporter, namely the extraneuronal monoamine transporter (EMT), by demonstrating its function and mRNA expression. Furthermore, we showed that the rapid, non-genomic inhibitory GS effect on EMT is likely mediated through the activation of specific K+ channels in the plasma membrane. We believe that our studies identified new molecular targets for GSs in modulating noradrenergic control of airway vascular tone.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalArchives of Physiology and Biochemistry
Volume111
Issue number4
DOIs
StatePublished - Oct 1 2003

Keywords

  • Bronchial circulation
  • Extraneuronal monoamine
  • Glucocorticoid
  • Nongenomic
  • Transporter
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Biochemistry

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