Molecular signaling in pathogenesis of craniosynostosis: The role of fibroblast growth factor and transforming growth factor-β

Harvey Chim, Sunil Manjila, Alan R. Cohen, Arun K. Gosain

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The interplay of signals between dura mater, suture mesenchyme, and brain is essential in determining the fate of cranial sutures and the pathogenesis of premature suture fusion leading to craniosynostosis. At the forefront of research into suture fusion is the role of fibroblast growth factor and transforming growth factor-β, which have been found to be critical in the cell-signaling cascade involved in aberrant suture fusion. In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-β in the etiopathogenesis of craniosynostosis.

Original languageEnglish (US)
Article numberE7
JournalNeurosurgical focus
Volume31
Issue number2
DOIs
StatePublished - Aug 1 2011

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Keywords

  • Craniosynostosis
  • Fibroblast growth factor
  • Molecular signaling
  • Pathogenesis
  • Transforming growth factor-beta

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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