Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

Giovana Thomas, Hari Nadiminti, Jacinto Regalado

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.

Original languageEnglish
Pages (from-to)347-363
Number of pages17
JournalInternational Journal of Experimental Pathology
Volume86
Issue number6
DOIs
StatePublished - Dec 1 2005

Fingerprint

Biomarkers
Vascular Endothelial Growth Factor Receptor
Smell
Genomic Instability
Cyclin D1
Matrix Metalloproteinases
Epidermal Growth Factor
Hearing
Therapeutics
Biopsy
Recurrence
Survival
Carcinoma, squamous cell of head and neck
Enzymes
Proteins

Keywords

  • Biomarkers
  • Gene expression profiles
  • Head and neck squamous cell carcinoma
  • Proteomics
  • Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. / Thomas, Giovana; Nadiminti, Hari; Regalado, Jacinto.

In: International Journal of Experimental Pathology, Vol. 86, No. 6, 01.12.2005, p. 347-363.

Research output: Contribution to journalArticle

@article{a215b7c7975d450ca9e9815c07c53afb,
title = "Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma",
abstract = "Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.",
keywords = "Biomarkers, Gene expression profiles, Head and neck squamous cell carcinoma, Proteomics, Survival",
author = "Giovana Thomas and Hari Nadiminti and Jacinto Regalado",
year = "2005",
month = "12",
day = "1",
doi = "10.1111/j.0959-9673.2005.00447.x",
language = "English",
volume = "86",
pages = "347--363",
journal = "International Journal of Experimental Pathology",
issn = "0959-9673",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

AU - Thomas, Giovana

AU - Nadiminti, Hari

AU - Regalado, Jacinto

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.

AB - Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox-2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.

KW - Biomarkers

KW - Gene expression profiles

KW - Head and neck squamous cell carcinoma

KW - Proteomics

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=28544438498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28544438498&partnerID=8YFLogxK

U2 - 10.1111/j.0959-9673.2005.00447.x

DO - 10.1111/j.0959-9673.2005.00447.x

M3 - Article

C2 - 16309541

AN - SCOPUS:28544438498

VL - 86

SP - 347

EP - 363

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

SN - 0959-9673

IS - 6

ER -