The biochemical basis of oxygen toxicity has been thoroughly investigated since the discovery that free radical intermediates are generated during normal cellular oxygen metabolism. Specific molecular sources and targets of partially reduced oxygen metabolites are present in cells and account for the pathophysiology of cellular and clinical oxygen toxicity. Oxygen-induced lung injury in experimental models can be minimized by new pharmacologic techniques, some of which quite effectively augment intracellular antioxidant defenses. The pathology of pulmonary oxygen toxicity resembles that of the adult respiratory distress syndrome in that the two share many basic mechanisms of cellular injury.
|Original language||English (US)|
|Number of pages||14|
|Journal||Clinics in Chest Medicine|
|State||Published - 1990|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine