Molecular, pharmacologic, and clinical aspects of oxygen-induced lung injury

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The biochemical basis of oxygen toxicity has been thoroughly investigated since the discovery that free radical intermediates are generated during normal cellular oxygen metabolism. Specific molecular sources and targets of partially reduced oxygen metabolites are present in cells and account for the pathophysiology of cellular and clinical oxygen toxicity. Oxygen-induced lung injury in experimental models can be minimized by new pharmacologic techniques, some of which quite effectively augment intracellular antioxidant defenses. The pathology of pulmonary oxygen toxicity resembles that of the adult respiratory distress syndrome in that the two share many basic mechanisms of cellular injury.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalClinics in Chest Medicine
Issue number1
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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