Molecular pathogenesis of diffuse large B-cell lymphoma

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's lymphomas. The pathogenesis of DLBCL is complex and heterogeneous. Recent studies using analysis of global gene expression with DNA microarrays and the classical molecular approaches demonstrate presence of several DLBCL subtypes characterized by different cells of origin, cytogenetic and molecular aberrations, and distinct pathogenesis. This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis.

Original languageEnglish
Pages (from-to)6351-6357
Number of pages7
JournalJournal of Clinical Oncology
Volume23
Issue number26
DOIs
StatePublished - Dec 1 2005

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Lymphoma, Large B-Cell, Diffuse
Oligonucleotide Array Sequence Analysis
Chromosome Aberrations
Non-Hodgkin's Lymphoma
Cell Biology
B-Lymphocytes
Gene Expression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Molecular pathogenesis of diffuse large B-cell lymphoma. / Lossos, Izidore.

In: Journal of Clinical Oncology, Vol. 23, No. 26, 01.12.2005, p. 6351-6357.

Research output: Contribution to journalArticle

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