Molecular pathogenesis of diffuse large B-cell lymphoma

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's lymphomas. The pathogenesis of DLBCL is complex and heterogeneous. Recent studies using analysis of global gene expression with DNA microarrays and the classical molecular approaches demonstrate presence of several DLBCL subtypes characterized by different cells of origin, cytogenetic and molecular aberrations, and distinct pathogenesis. This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis.

Original languageEnglish (US)
Pages (from-to)6351-6357
Number of pages7
JournalJournal of Clinical Oncology
Issue number26
StatePublished - 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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