Molecular Pathogenesis and Interventional Strategies for Alzheimer's Disease: Promises and Pitfalls

Shashikala Bhute, Deepaneeta Sarmah, Aishika Datta, Pallavi Rane, Amit Shard, Avirag Goswami, Anupom Borah, Kiran Kalia, Kunjan R. Dave, Pallab Bhattacharya

Research output: Contribution to journalReview article

Abstract

Alzheimer's disease (AD) is a debilitating disorder characterized by age-related dementia, which has no effective treatment to date. β-Amyloid depositions and hyperphosphorylated tau proteins are the main pathological hallmarks, along with oxidative stress, N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity, and low levels of acetylcholine. Current pharmacotherapy for AD only provides symptomatic relief and limited improvement in cognitive functions. Many molecules have been explored that show promising outcomes in AD therapy and can regulate cellular survival through different pathways. To have a vivid approach to strategize the treatment regimen, AD physiopathology should be better explained considering diverse etiological factors in conjunction with biochemical disturbances. This Review attempts to discuss different disease modification approaches and address the novel therapeutic targets of AD that might pave the way for new drug discovery using the well-defined targets for therapy of the disease.

Original languageEnglish (US)
Pages (from-to)472-488
Number of pages17
JournalACS Pharmacology and Translational Science
Volume3
Issue number3
DOIs
StatePublished - Jun 12 2020

Keywords

  • apolipoprotein
  • immune system
  • proteoglycans
  • PrP
  • RanBP9
  • sirtuins

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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  • Cite this

    Bhute, S., Sarmah, D., Datta, A., Rane, P., Shard, A., Goswami, A., Borah, A., Kalia, K., Dave, K. R., & Bhattacharya, P. (2020). Molecular Pathogenesis and Interventional Strategies for Alzheimer's Disease: Promises and Pitfalls. ACS Pharmacology and Translational Science, 3(3), 472-488. https://doi.org/10.1021/acsptsci.9b00104