The development of the inner ear involves a complex series of tissue interactions mediated by trophic signals. Recent studies have shown that various homeotic genes, which specify cell position during development, are active in the formation of the otocyst. These genes act on inner ear development by affecting hindbrain development. Further along in development, a wide array of proto-oncogenes and growth factors affects more specific portions of inner ear development. Understanding the molecular basis of inner ear development may lead to a clearer understanding of congenital malformations and the effect of teratogens on the ear, and eventually, to the development of molecular therapies for a wide range of otopathy.
|Original language||English (US)|
|Number of pages||7|
|Journal||Current Opinion in Otolaryngology and Head and Neck Surgery|
|State||Published - Jan 1 1995|
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