Molecular mechanisms of inner ear development

H. Staecker, T. R. Van de Water

Research output: Contribution to journalReview articlepeer-review


The development of the inner ear involves a complex series of tissue interactions mediated by trophic signals. Recent studies have shown that various homeotic genes, which specify cell position during development, are active in the formation of the otocyst. These genes act on inner ear development by affecting hindbrain development. Further along in development, a wide array of proto-oncogenes and growth factors affects more specific portions of inner ear development. Understanding the molecular basis of inner ear development may lead to a clearer understanding of congenital malformations and the effect of teratogens on the ear, and eventually, to the development of molecular therapies for a wide range of otopathy.

Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number5
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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