Abstract
Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.
Original language | English (US) |
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Pages (from-to) | 89-98 |
Number of pages | 10 |
Journal | Microbes and Infection |
Volume | 12 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2010 |
Keywords
- Enterotoxigenic Escherichia coli
- Enterotoxins
- Escherichia coli vaccines
- Genomics
- Pathogenesis
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases