Abstract
Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.
| Original language | English |
|---|---|
| Pages (from-to) | 89-98 |
| Number of pages | 10 |
| Journal | Microbes and Infection |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2010 |
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Keywords
- Enterotoxigenic Escherichia coli
- Enterotoxins
- Escherichia coli vaccines
- Genomics
- Pathogenesis
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases
Cite this
Molecular mechanisms of enterotoxigenic Escherichia coli infection. / Fleckenstein, James M.; Hardwidge, Philip R.; Munson, George; Rasko, David A.; Sommerfelt, Halvor; Steinsland, Hans.
In: Microbes and Infection, Vol. 12, No. 2, 01.02.2010, p. 89-98.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular mechanisms of enterotoxigenic Escherichia coli infection
AU - Fleckenstein, James M.
AU - Hardwidge, Philip R.
AU - Munson, George
AU - Rasko, David A.
AU - Sommerfelt, Halvor
AU - Steinsland, Hans
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.
AB - Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.
KW - Enterotoxigenic Escherichia coli
KW - Enterotoxins
KW - Escherichia coli vaccines
KW - Genomics
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=75149167834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149167834&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2009.10.002
DO - 10.1016/j.micinf.2009.10.002
M3 - Article
C2 - 19883790
AN - SCOPUS:75149167834
VL - 12
SP - 89
EP - 98
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
IS - 2
ER -