Molecular mechanisms of enterotoxigenic Escherichia coli infection

James M. Fleckenstein, Philip R. Hardwidge, George Munson, David A. Rasko, Halvor Sommerfelt, Hans Steinsland

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalMicrobes and Infection
Volume12
Issue number2
DOIs
StatePublished - Feb 1 2010

Fingerprint

Enterotoxigenic Escherichia coli
Escherichia coli Infections
Hot Temperature
Host-Pathogen Interactions
Enterotoxins
Proteomics
Developing Countries
Diarrhea
Vaccines
Technology
Infection

Keywords

  • Enterotoxigenic Escherichia coli
  • Enterotoxins
  • Escherichia coli vaccines
  • Genomics
  • Pathogenesis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Fleckenstein, J. M., Hardwidge, P. R., Munson, G., Rasko, D. A., Sommerfelt, H., & Steinsland, H. (2010). Molecular mechanisms of enterotoxigenic Escherichia coli infection. Microbes and Infection, 12(2), 89-98. https://doi.org/10.1016/j.micinf.2009.10.002

Molecular mechanisms of enterotoxigenic Escherichia coli infection. / Fleckenstein, James M.; Hardwidge, Philip R.; Munson, George; Rasko, David A.; Sommerfelt, Halvor; Steinsland, Hans.

In: Microbes and Infection, Vol. 12, No. 2, 01.02.2010, p. 89-98.

Research output: Contribution to journalArticle

Fleckenstein, JM, Hardwidge, PR, Munson, G, Rasko, DA, Sommerfelt, H & Steinsland, H 2010, 'Molecular mechanisms of enterotoxigenic Escherichia coli infection', Microbes and Infection, vol. 12, no. 2, pp. 89-98. https://doi.org/10.1016/j.micinf.2009.10.002
Fleckenstein JM, Hardwidge PR, Munson G, Rasko DA, Sommerfelt H, Steinsland H. Molecular mechanisms of enterotoxigenic Escherichia coli infection. Microbes and Infection. 2010 Feb 1;12(2):89-98. https://doi.org/10.1016/j.micinf.2009.10.002
Fleckenstein, James M. ; Hardwidge, Philip R. ; Munson, George ; Rasko, David A. ; Sommerfelt, Halvor ; Steinsland, Hans. / Molecular mechanisms of enterotoxigenic Escherichia coli infection. In: Microbes and Infection. 2010 ; Vol. 12, No. 2. pp. 89-98.
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