Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes

Eckhard R. Podack

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


This review summarizes the molecular events resulting in the formation of membrane lesions by lymphocytes and by complement and our knowledge of additional sytolytic factors. It will become apparent that there are striking analogies in the morphology and function of the tubular complexes, their mode of assembly, as well as their utilization as transmembrane channels for entry of cytolytic factors.

Original languageEnglish (US)
Pages (from-to)133-170
Number of pages38
JournalJournal of cellular biochemistry
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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