Molecular mechanisms of CNS synaptogenesis

Craig C. Garner, R. Grace Zhai, Eckart D. Gundelfinger, Noam E. Ziv

Research output: Contribution to journalReview article

135 Scopus citations

Abstract

Synapses of the mammalian CNS are asymmetric sites of cell-cell adhesion between nerve cells. They are designed to mediate the rapid and efficient transmission of signals from the presynaptic bouton of one neuron to the postsynaptic plasma membrane of a second neuron. Significant progress has been made in the characterization of the structural, functional and developmental assembly of CNS synapses. Recent progress has been made in understanding the molecular and cellular mechanisms that underlie synaptogenesis, in particular that of glutamatergic synapses of the CNS.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalTrends in Neurosciences
Volume25
Issue number5
DOIs
StatePublished - May 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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