Abstract
Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.
| Original language | English |
|---|---|
| Pages (from-to) | 4311-4314 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 61 |
| Issue number | 11 |
| State | Published - Jun 1 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Molecular identification of latent precancers in histologically normal endometrium. / Mutter, G. L.; Ince, Tan; Baak, J. P A; Kust, G. A.; Zhou, X. P.; Eng, C.
In: Cancer Research, Vol. 61, No. 11, 01.06.2001, p. 4311-4314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular identification of latent precancers in histologically normal endometrium
AU - Mutter, G. L.
AU - Ince, Tan
AU - Baak, J. P A
AU - Kust, G. A.
AU - Zhou, X. P.
AU - Eng, C.
PY - 2001/6/1
Y1 - 2001/6/1
N2 - Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.
AB - Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035361713&partnerID=8YFLogxK
M3 - Article
C2 - 11389050
AN - SCOPUS:0035361713
VL - 61
SP - 4311
EP - 4314
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 11
ER -