Molecular identification of latent precancers in histologically normal endometrium

George L. Mutter, Tan A. Ince, Jan P.A. Baak, Gregory A. Kust, Xiao Ping Zhou, Charis Eng

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.

Original languageEnglish (US)
Pages (from-to)4311-4314
Number of pages4
JournalCancer Research
Issue number11
StatePublished - Jun 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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