Molecular identification of latent precancers in histologically normal endometrium

G. L. Mutter, Tan Ince, J. P A Baak, G. A. Kust, X. P. Zhou, C. Eng

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.

Original languageEnglish
Pages (from-to)4311-4314
Number of pages4
JournalCancer Research
Volume61
Issue number11
StatePublished - Jun 1 2001
Externally publishedYes

Fingerprint

PTEN Phosphohydrolase
Sequence Deletion
Menstrual Cycle
Endometrium
Tumor Suppressor Genes
Carcinogenesis
Mutation
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mutter, G. L., Ince, T., Baak, J. P. A., Kust, G. A., Zhou, X. P., & Eng, C. (2001). Molecular identification of latent precancers in histologically normal endometrium. Cancer Research, 61(11), 4311-4314.

Molecular identification of latent precancers in histologically normal endometrium. / Mutter, G. L.; Ince, Tan; Baak, J. P A; Kust, G. A.; Zhou, X. P.; Eng, C.

In: Cancer Research, Vol. 61, No. 11, 01.06.2001, p. 4311-4314.

Research output: Contribution to journalArticle

Mutter, GL, Ince, T, Baak, JPA, Kust, GA, Zhou, XP & Eng, C 2001, 'Molecular identification of latent precancers in histologically normal endometrium', Cancer Research, vol. 61, no. 11, pp. 4311-4314.
Mutter GL, Ince T, Baak JPA, Kust GA, Zhou XP, Eng C. Molecular identification of latent precancers in histologically normal endometrium. Cancer Research. 2001 Jun 1;61(11):4311-4314.
Mutter, G. L. ; Ince, Tan ; Baak, J. P A ; Kust, G. A. ; Zhou, X. P. ; Eng, C. / Molecular identification of latent precancers in histologically normal endometrium. In: Cancer Research. 2001 ; Vol. 61, No. 11. pp. 4311-4314.
@article{6bb9305040e943d5a14880a6f1a948b5,
title = "Molecular identification of latent precancers in histologically normal endometrium",
abstract = "Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43{\%} of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.",
author = "Mutter, {G. L.} and Tan Ince and Baak, {J. P A} and Kust, {G. A.} and Zhou, {X. P.} and C. Eng",
year = "2001",
month = "6",
day = "1",
language = "English",
volume = "61",
pages = "4311--4314",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "11",

}

TY - JOUR

T1 - Molecular identification of latent precancers in histologically normal endometrium

AU - Mutter, G. L.

AU - Ince, Tan

AU - Baak, J. P A

AU - Kust, G. A.

AU - Zhou, X. P.

AU - Eng, C.

PY - 2001/6/1

Y1 - 2001/6/1

N2 - Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.

AB - Discovery of somatically mutated cells in human tissues has been less frequent than would be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as an early marker for endometrial carcinogenesis, and we show that 43% of histologically normal premenopausal endometria contain rare glands that fail to express PTEN protein because of mutation and/or deletion. These persist between menstrual cycles. Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting.

UR - http://www.scopus.com/inward/record.url?scp=0035361713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035361713&partnerID=8YFLogxK

M3 - Article

C2 - 11389050

AN - SCOPUS:0035361713

VL - 61

SP - 4311

EP - 4314

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 11

ER -