Molecular genetic methods in the diagnosis of hematologic neoplasms

Filiz Şen, Francisco Vega, L. Jeffrey Medeiros

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Leukemias and lymphomas are monoclonal neoplasms that arise as a result of molecular abnormalities. These abnormalites are diverse but can be grouped into two general categories, chromosomal translocations that usually result in oncogene activation and inactivation of tumor suppressor genes. Recent advances in our understanding of chromosomal translocations have led to improved classification of leukemias and lymphomas. For example, the t(9;22)(q34;q11) is now considered a defining feature of chronic myeloid leukemia, and the t(2;5)(p23;q35) defines a clinically and biologically unique subset of anaplastic large cell lymphomas. In this review, we focus on chromosomal translocations in hematologic neoplasms and the techniques used for their detection. We also briefly discuss tumor suppressor genes and assessment of clonality in lymphoid neoplasms.

Original languageEnglish (US)
Pages (from-to)72-93
Number of pages22
JournalSeminars in Diagnostic Pathology
Volume19
Issue number2
StatePublished - May 20 2002

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Keywords

  • Chromosomal translocation
  • Leukemia
  • Molecular diagnostics
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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