In the study of human immunodeficiency virus type 1 (HIV-1) maturing dynamics it is shown that at initial stages of HIV-1 virion production the so-called early virus particles are formed, which do not contain the conical core and don't possess infectivity. At the same time, virions contain mature structural Gag proteins. At the second production stage, about after 48 hours from MT-4 cells infecting, formed are infective-complementary virus particles containing characteristic for HIV-1 conical core. Thus, acquiring of infectivity and morphological restructuring of virus particles aren't correlated with proteolytic processing of p55 precursor.
|Original language||English (US)|
|Number of pages||3|
|Journal||Doklady Akademii Nauk|
|State||Published - Dec 22 2005|
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