Molecular factors required for human immunodeficiency virus type 1 infectivity

A. G. Bukrinskaya, G. K. Vorkunova, M. E. Burshtejn, T. V. Gorodnicheva, Mario Stevenson

Research output: Contribution to journalArticle

Abstract

In the study of human immunodeficiency virus type 1 (HIV-1) maturing dynamics it is shown that at initial stages of HIV-1 virion production the so-called early virus particles are formed, which do not contain the conical core and don't possess infectivity. At the same time, virions contain mature structural Gag proteins. At the second production stage, about after 48 hours from MT-4 cells infecting, formed are infective-complementary virus particles containing characteristic for HIV-1 conical core. Thus, acquiring of infectivity and morphological restructuring of virus particles aren't correlated with proteolytic processing of p55 precursor.

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalDoklady Akademii Nauk
Volume403
Issue number3
StatePublished - Dec 22 2005
Externally publishedYes

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Virion
HIV-1
gag Gene Products

ASJC Scopus subject areas

  • General

Cite this

Bukrinskaya, A. G., Vorkunova, G. K., Burshtejn, M. E., Gorodnicheva, T. V., & Stevenson, M. (2005). Molecular factors required for human immunodeficiency virus type 1 infectivity. Doklady Akademii Nauk, 403(3), 418-420.

Molecular factors required for human immunodeficiency virus type 1 infectivity. / Bukrinskaya, A. G.; Vorkunova, G. K.; Burshtejn, M. E.; Gorodnicheva, T. V.; Stevenson, Mario.

In: Doklady Akademii Nauk, Vol. 403, No. 3, 22.12.2005, p. 418-420.

Research output: Contribution to journalArticle

Bukrinskaya, AG, Vorkunova, GK, Burshtejn, ME, Gorodnicheva, TV & Stevenson, M 2005, 'Molecular factors required for human immunodeficiency virus type 1 infectivity', Doklady Akademii Nauk, vol. 403, no. 3, pp. 418-420.
Bukrinskaya AG, Vorkunova GK, Burshtejn ME, Gorodnicheva TV, Stevenson M. Molecular factors required for human immunodeficiency virus type 1 infectivity. Doklady Akademii Nauk. 2005 Dec 22;403(3):418-420.
Bukrinskaya, A. G. ; Vorkunova, G. K. ; Burshtejn, M. E. ; Gorodnicheva, T. V. ; Stevenson, Mario. / Molecular factors required for human immunodeficiency virus type 1 infectivity. In: Doklady Akademii Nauk. 2005 ; Vol. 403, No. 3. pp. 418-420.
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