Molecular evidence for arterial repair in atherosclerosis

Ravi Karra, Sreekanth Vemullapalli, Chunming Dong, Edward E. Herderick, Xiaohua Song, Kathy Slosek, Joseph R. Nevins, Mike West, Pascal J. Goldschmidt-Clermont, David Seo

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Atherosclerosis is a chronic inflammatory process and progresses through characteristic morphologic stages. We have shown previously that chronically injecting bone-marrow-derived vascular progenitor cells can effect arterial repair. This repair capacity depends on the age of the injected marrow cells, suggesting a progressive decline in progenitor cell function. We hypothesized that the progression of atherosclerosis coincides with the deteriorating repair capacity of the bone marrow. Here, we ascribe patterns of gene expression that accurately and reproducibly identify specific disease states in murine atherosclerosis. We then use these expression patterns to determine the point in the disease process at which the repair of arteries by competent bone marrow cells ceases to be efficient. We show that the loss of the molecular signature for competent repair is concurrent with the initiation of atherosclerotic lesions. This work provides a previously unreported comprehensive molecular data set using broad-based analysis that links the loss of successful repair with the progression of a chronic illness.

Original languageEnglish (US)
Pages (from-to)16789-16794
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number46
DOIs
StatePublished - Nov 15 2005

Keywords

  • Aging
  • Bone marrow obsolescence
  • Genomic
  • Inflammation
  • Vascular progenitor cell

ASJC Scopus subject areas

  • Genetics
  • General

Fingerprint Dive into the research topics of 'Molecular evidence for arterial repair in atherosclerosis'. Together they form a unique fingerprint.

  • Cite this

    Karra, R., Vemullapalli, S., Dong, C., Herderick, E. E., Song, X., Slosek, K., Nevins, J. R., West, M., Goldschmidt-Clermont, P. J., & Seo, D. (2005). Molecular evidence for arterial repair in atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America, 102(46), 16789-16794. https://doi.org/10.1073/pnas.0507718102