Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis

Mary C. Booth, Kenneth L. Hatter, Darlene Miller, Janet Davis, Regis Kowalski, David W. Parke, James Chodosh, Bradley D. Jett, Michelle C. Callegan, Rebecca Penland, Michael S. Gilmore

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Genomic DNA fingerprint analysis was performed on 39 Staphylococcus aureus and 28 Enterococcus faecalis endophthalmitis isolates collected from multiple clinical centers. Among 21 S. aureus genomic DNA fingerprint patterns identified, five clonotypes were recovered from multiple unrelated patients and accounted for 58.9% (23 of 39) of the isolates analyzed. Compared with strains having unique genomic DNA fingerprint patterns, the S. aureus clonotypes occurring more than once were more likely to result in visual acuities of 20/200 or worse (P = 0.036 [χ2 test]). In contrast to the S. aureus isolates, the E. faecalis endophthalmitis isolates were a clonally diverse population, enriched for the expression of a known toxin, cytolysin, which is plasmid encoded.

Original languageEnglish (US)
Pages (from-to)356-360
Number of pages5
JournalInfection and immunity
Issue number1
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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