Molecular biology of leukemia.

A. Jakubowiak, J. Cammenga, R. Sokolic, S. Alvarez, G. Jackson, C. Hedvat, S. D. Nimer

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Identification and characterization of leukemia-related chromosomal translocations have had significant impact on all aspects of the management of acute leukemia, including its diagnosis, assignment of prognosis, and development of an appropriate treatment plan. Several genes are recurrent targets of chromosomal abnormalities, suggesting that they play a key role in leukemogenesis. Significant progress has been made to define potentially unifying molecular mechanisms of leukemic transformation. Hopefully, these findings will provide the basis for molecularly targeted therapies for leukemia.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalCurrent oncology reports
Volume2
Issue number2
DOIs
StatePublished - Mar 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology

Cite this

Jakubowiak, A., Cammenga, J., Sokolic, R., Alvarez, S., Jackson, G., Hedvat, C., & Nimer, S. D. (2000). Molecular biology of leukemia. Current oncology reports, 2(2), 123-131. https://doi.org/10.1007/s11912-000-0083-z