Molecular approaches to resolve diagnostic dilemmas: The case of gastrointestinal stromal tumor and leiomyosarcoma

Jonathan C. Trent, Alexander J.F. Lazar, Wei Zhang

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Gastrointestinal stromal tumors (GISTs) and leiomyosarcomas (LMSs) are common types of mesenchymal tumors that may present a diagnostic challenge. GISTs have frequent overexpression of Kit and often encode for mutation of the KIT oncogene. In addition, patients usually experience a favorable response to targeted therapy with imatinib mesylate (Gleevec®, STI-571), but not cytotoxic chemotherapy. Up to 5% of GISTs can be completely negative for Kit on immunohistochemistry. Conversely, LIMSs may rarely express Kit, but are virtually never associated with an activating KIT mutation, and are often effectively treated with cytotoxic chemotherapy but are resistant to imatinib. To aid in resolution of this clincal challenge, we performed a whole-genome gene expression study on 71 well-defined GIST and LMS samples with development of a robust, novel approach to molecular classification discussed herein.

Original languageEnglish (US)
Pages (from-to)629-637
Number of pages9
JournalFuture Oncology
Volume3
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Clinical
  • Diagnosis
  • Gastrointestinal
  • GIST
  • Imatinib
  • Leiomyosarcoma
  • Microarray
  • Sarcoma
  • Sunitinib
  • Targeted therapy
  • Treatment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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