Molar quantitation of in vivo proton metabolites in human brain with 3D magnetic resonance spectroscopic imaging

C. A. Husted, J. H. Duijn, G. B. Matson, A. A. Maudsley, M. W. Weiner

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A method for molar quantitation of in vivo proton metabolites in human brain with three-dimensional (3D) proton magnetic resonance spectroscopic imaging (MRSI) is described. The method relies on comparison of brain and calibration phantom measurements, with corrections for coil loading, and spin-lattice and spin-spin relaxation times. A 3D proton MRSI pulse sequence was developed which acquires two echoes and enables acquisition of both the TMS coil loading reference phantom and proton metabolite signals from a single experiment. With the aqueous fraction (tissue water) taken into account, the calculated molar concentrations from 24 centrum semiovale white matter voxels from 4 control subjects were (mmol/l ± SD): N-acetyl aspartate = 14.6 ± 2.8, total creatine + phosphocreatine = 6.0 ± 1.2, total choline = 1.9 ± 0.4. These values are equivalent to previously reported results obtained from single volume localized proton magnetic resonance spectroscopy.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalMagnetic Resonance Imaging
Volume12
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Brain
  • Magnetic resonance spectroscopic imaging
  • Proton spectroscopy
  • Quantitation

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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