Modulation of suppression of mitogen-induced T cell-dependent B cell responses by natural killer cells

Paul Katz, Gail Whalen, S. Ray Mitchell, Thomas R. Cupps, Mishell Evans

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We examined the ability of human natural killer (NK) cells to modulate pokeweed mitogen (PWM)-induced polyclonal antibody production. Highly purified NK cells inhibited plaque-forming cell (PFC) responses and this suppression could be substantially increased by preincubation of NK cells with the known enhancers of NK cell lytic activity, interferon (IFN)-α, IFN-γ, and interleukin-2. Additionally, costimulation of NK cells with two anti-CD2 antibodies (9-1 and 9.6), which recognize different epitopes on the CD2 molecule, also augmented the inhibitory effect. When subpopulations of NK cells were assayed for suppressor cell activity, this activity was primarily mediated by NK cells bearing Leu-7 but not Leu-2 (CD8) antigens. Thus, alteration of NK cell lytic activity may have significant effects on the immunoregulatory functions of these cells, which may have important implications for the in vivo manipulation of cytotoxic responses.

Original languageEnglish (US)
Pages (from-to)148-155
Number of pages8
JournalClinical Immunology and Immunopathology
Volume55
Issue number1
DOIs
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Fingerprint Dive into the research topics of 'Modulation of suppression of mitogen-induced T cell-dependent B cell responses by natural killer cells'. Together they form a unique fingerprint.

  • Cite this