Modulation of procainamide toxicity by selenium-enriched yeast in rats

Michal J Toborek, Krystyna Magner-Wróbel, Marian Drózdz, Alojzy Danch, Ewa Kopieczna-Grzebieniak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Free radical processes are proposed to play a crucial role in the development of procainamide adverse effects. Therefore, selenium, as a potent antioxidant, may modified procainamide toxicity. To test this hypothesis plasma and liver thiobarbituric acid-reacting substances (TBARS), plasma antioxidant activity (AOA), erythrocyte and liver superoxide dismutase (SOD), catalase, as well as selenium-dependent glutathione peroxidase (Se-GPX) were determined in the following four groups of rats: selenium-treated (Se), procainamide-treated (P), procainamide and selenium-treated (P + Se), and control (C). Morphological studies of leukocytes [tested for lupus erythematosus (LE) cells] and liver were also made. Atypical, i.e. enlarged and swollen, leukocytes resulting from procainamide and selenium treatment were observed. These changes were found in four out of five rats in the Se group, eight out of ten in the P group, and in seven out of ten in the P + Se group. LE-like cells were observed in two rats in the P + Se group. A statistically significant decrease in plasma and liver TBARS by 20% and 36%, respectively, increased activity of SOD by 20%, catalase by 48% and Se-GPX by 15% in erythrocytes, and decreased activity of liver SOD by 17% and catalase by 22% were found in the P + Se group as compared to the P group. These results indicated that selenium exerted antioxidant effects on the procainamide-treated rats. However, selenium did not prevent the development of disturbances in leukocyte morphology, on the contrary, it possibly promoted the conversion of leukocytes to LE cells.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalArchives of Toxicology
Volume67
Issue number10
DOIs
StatePublished - Dec 1 1993
Externally publishedYes

Fingerprint

Procainamide
Selenium
Yeast
Toxicity
Rats
Yeasts
Modulation
Liver
Leukocytes
Catalase
Superoxide Dismutase
Antioxidants
Glutathione Peroxidase
Plasmas
Erythrocytes
Free Radicals

Keywords

  • Antioxidant enzymes
  • LE-like cells
  • Lupus-like syndrome
  • Procainamide
  • Selenium
  • TBARS

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Toborek, M. J., Magner-Wróbel, K., Drózdz, M., Danch, A., & Kopieczna-Grzebieniak, E. (1993). Modulation of procainamide toxicity by selenium-enriched yeast in rats. Archives of Toxicology, 67(10), 691-695. https://doi.org/10.1007/BF01973693

Modulation of procainamide toxicity by selenium-enriched yeast in rats. / Toborek, Michal J; Magner-Wróbel, Krystyna; Drózdz, Marian; Danch, Alojzy; Kopieczna-Grzebieniak, Ewa.

In: Archives of Toxicology, Vol. 67, No. 10, 01.12.1993, p. 691-695.

Research output: Contribution to journalArticle

Toborek, MJ, Magner-Wróbel, K, Drózdz, M, Danch, A & Kopieczna-Grzebieniak, E 1993, 'Modulation of procainamide toxicity by selenium-enriched yeast in rats', Archives of Toxicology, vol. 67, no. 10, pp. 691-695. https://doi.org/10.1007/BF01973693
Toborek MJ, Magner-Wróbel K, Drózdz M, Danch A, Kopieczna-Grzebieniak E. Modulation of procainamide toxicity by selenium-enriched yeast in rats. Archives of Toxicology. 1993 Dec 1;67(10):691-695. https://doi.org/10.1007/BF01973693
Toborek, Michal J ; Magner-Wróbel, Krystyna ; Drózdz, Marian ; Danch, Alojzy ; Kopieczna-Grzebieniak, Ewa. / Modulation of procainamide toxicity by selenium-enriched yeast in rats. In: Archives of Toxicology. 1993 ; Vol. 67, No. 10. pp. 691-695.
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