Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

Andrea Marzi, Daniel A. Mitchell, Chawaree Chaipan, Tanja Fisch, Robert W. Doms, Mary Carrington, Ronald C. Desrosiers, Stefan Pöhlmann

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.

Original languageEnglish (US)
Pages (from-to)322-330
Number of pages9
JournalVirology
Volume368
Issue number2
DOIs
StatePublished - Nov 25 2007
Externally publishedYes

Keywords

  • Antibody
  • Attachment
  • DC-SIGN
  • MBL
  • Neutralization
  • SIV

ASJC Scopus subject areas

  • Virology

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