Abstract
The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.
Original language | English (US) |
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Pages (from-to) | 322-330 |
Number of pages | 9 |
Journal | Virology |
Volume | 368 |
Issue number | 2 |
DOIs | |
State | Published - Nov 25 2007 |
Externally published | Yes |
Keywords
- Antibody
- Attachment
- DC-SIGN
- MBL
- Neutralization
- SIV
ASJC Scopus subject areas
- Virology