Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

Andrea Marzi; Daniel A. Mitchell; Chawaree Chaipan; Tanja Fisch; Robert W. Doms; Mary Carrington; Ronald C. Desrosiers; Stefan Pöhlmann

doi:10.1016/j.virol.2007.07.004

Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

Andrea Marzi, Daniel A. Mitchell, Chawaree Chaipan, Tanja Fisch, Robert W. Doms, Mary Carrington, Ronald C. Desrosiers, Stefan Pöhlmann

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.

Original language	English (US)
Pages (from-to)	322-330
Number of pages	9
Journal	Virology
Volume	368
Issue number	2
DOIs	https://doi.org/10.1016/j.virol.2007.07.004
State	Published - Nov 25 2007
Externally published	Yes

Keywords

Antibody
Attachment
DC-SIGN
MBL
Neutralization
SIV

ASJC Scopus subject areas

Virology

Access to Document

10.1016/j.virol.2007.07.004

Fingerprint Dive into the research topics of 'Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin'. Together they form a unique fingerprint.

Cite this

@article{c9a4b7d0725c4c25be007b49c2924b58,

title = "Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin",

abstract = "The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.",

keywords = "Antibody, Attachment, DC-SIGN, MBL, Neutralization, SIV",

author = "Andrea Marzi and Mitchell, {Daniel A.} and Chawaree Chaipan and Tanja Fisch and Doms, {Robert W.} and Mary Carrington and Desrosiers, {Ronald C.} and Stefan P{\"o}hlmann",

year = "2007",

month = nov,

day = "25",

doi = "10.1016/j.virol.2007.07.004",

language = "English (US)",

volume = "368",

pages = "322--330",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin

AU - Marzi, Andrea

AU - Mitchell, Daniel A.

AU - Chaipan, Chawaree

AU - Fisch, Tanja

AU - Doms, Robert W.

AU - Carrington, Mary

AU - Desrosiers, Ronald C.

AU - Pöhlmann, Stefan

PY - 2007/11/25

Y1 - 2007/11/25

N2 - The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.

AB - The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.

KW - Antibody

KW - Attachment

KW - DC-SIGN

KW - MBL

KW - Neutralization

KW - SIV

UR - http://www.scopus.com/inward/record.url?scp=35548993574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35548993574&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2007.07.004

DO - 10.1016/j.virol.2007.07.004

M3 - Article

C2 - 17659761

AN - SCOPUS:35548993574

VL - 368

SP - 322

EP - 330

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -