@article{c9a4b7d0725c4c25be007b49c2924b58,
title = "Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin",
abstract = "The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.",
keywords = "Antibody, Attachment, DC-SIGN, MBL, Neutralization, SIV",
author = "Andrea Marzi and Mitchell, {Daniel A.} and Chawaree Chaipan and Tanja Fisch and Doms, {Robert W.} and Mary Carrington and Desrosiers, {Ronald C.} and Stefan P{\"o}hlmann",
note = "Funding Information: The following reagent was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID, NIH: Monoclonal antibody 2G12 from H. Katinger. We would like to thank B. Fleckenstein, K. von der Mark and T. F. Schulz for support. A.M., T.F. and S.P. were supported by SFB 466. C.C. was supported by GK 1071. D.M. is a Research Councils UK Fellow. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Heath and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.",
year = "2007",
month = nov,
day = "25",
doi = "10.1016/j.virol.2007.07.004",
language = "English (US)",
volume = "368",
pages = "322--330",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",
}