CSF-dependent myeloid colony growth can be augmented or inhibited by a number of modulating factors. PGs of the E series are known to inhibit colony formation. The antagonistic actions of PGE and PGF in many biological systems prompted us to compare their effects on myelopoiesis in vitro. PGF2α at an optimal concentration of 1 × 10-9M increased colony formation by 50% over that stimulated by CSF alone. Similar augmentation was also observed from 16,16-dimethyl PGF2α, PGF1α, 6-keto PGF1α, and MIX. In contrast PGE1, PGE2, and 15(S),15-methyl PGE, inhibited colony growth. Simulation by PGF reflected an absolute increase in granulocytic colonies, whereas inhibition by PGE affected both granulocyte and macrophage colony formation. The relative levels of PGE and PGF may play a determining role in the modulation of granulopoiesis.
|Original language||English (US)|
|Number of pages||8|
|Journal||The Journal of Laboratory and Clinical Medicine|
|State||Published - Dec 1978|
ASJC Scopus subject areas
- Pathology and Forensic Medicine