Abstract
CSF-dependent myeloid colony growth can be augmented or inhibited by a number of modulating factors. PGs of the E series are known to inhibit colony formation. The antagonistic actions of PGE and PGF in many biological systems prompted us to compare their effects on myelopoiesis in vitro. PGF2α at an optimal concentration of 1 × 10-9M increased colony formation by 50% over that stimulated by CSF alone. Similar augmentation was also observed from 16,16-dimethyl PGF2α, PGF1α, 6-keto PGF1α, and MIX. In contrast PGE1, PGE2, and 15(S),15-methyl PGE, inhibited colony growth. Simulation by PGF reflected an absolute increase in granulocytic colonies, whereas inhibition by PGE affected both granulocyte and macrophage colony formation. The relative levels of PGE and PGF may play a determining role in the modulation of granulopoiesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 983-990 |
| Number of pages | 8 |
| Journal | The Journal of laboratory and clinical medicine |
| Volume | 92 |
| Issue number | 6 |
| State | Published - 1978 |
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ASJC Scopus subject areas
- Medicine(all)
- Pathology and Forensic Medicine
Cite this
Modulation of granulopoiesis : opposing roles of prostaglandins F and E. / Miller, A. M.; Russell, T. R.; Gross, M. A.; Yunis, Adel A.
In: The Journal of laboratory and clinical medicine, Vol. 92, No. 6, 1978, p. 983-990.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of granulopoiesis
T2 - opposing roles of prostaglandins F and E
AU - Miller, A. M.
AU - Russell, T. R.
AU - Gross, M. A.
AU - Yunis, Adel A
PY - 1978
Y1 - 1978
N2 - CSF-dependent myeloid colony growth can be augmented or inhibited by a number of modulating factors. PGs of the E series are known to inhibit colony formation. The antagonistic actions of PGE and PGF in many biological systems prompted us to compare their effects on myelopoiesis in vitro. PGF2α at an optimal concentration of 1 × 10-9M increased colony formation by 50% over that stimulated by CSF alone. Similar augmentation was also observed from 16,16-dimethyl PGF2α, PGF1α, 6-keto PGF1α, and MIX. In contrast PGE1, PGE2, and 15(S),15-methyl PGE, inhibited colony growth. Simulation by PGF reflected an absolute increase in granulocytic colonies, whereas inhibition by PGE affected both granulocyte and macrophage colony formation. The relative levels of PGE and PGF may play a determining role in the modulation of granulopoiesis.
AB - CSF-dependent myeloid colony growth can be augmented or inhibited by a number of modulating factors. PGs of the E series are known to inhibit colony formation. The antagonistic actions of PGE and PGF in many biological systems prompted us to compare their effects on myelopoiesis in vitro. PGF2α at an optimal concentration of 1 × 10-9M increased colony formation by 50% over that stimulated by CSF alone. Similar augmentation was also observed from 16,16-dimethyl PGF2α, PGF1α, 6-keto PGF1α, and MIX. In contrast PGE1, PGE2, and 15(S),15-methyl PGE, inhibited colony growth. Simulation by PGF reflected an absolute increase in granulocytic colonies, whereas inhibition by PGE affected both granulocyte and macrophage colony formation. The relative levels of PGE and PGF may play a determining role in the modulation of granulopoiesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018240818&partnerID=8YFLogxK
M3 - Article
C2 - 739176
AN - SCOPUS:0018240818
VL - 92
SP - 983
EP - 990
JO - Translational Research
JF - Translational Research
SN - 1931-5244
IS - 6
ER -