Modulation of cell proliferation and gene expression by α-tocopheryl phosphates: Relevance to atherosclerosis and inflammation

Esra Ogru, Roksan Libinaki, Robert Gianello, Simon West, Adelina Munteanu, Jean Marc Zingg, Angelo Azzi

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The effect of a mixture of α-tocopheryl phosphate plus di-α-tocopheryl phosphate (TPm) was studied in vitro on two cell lines, RASMC (from rat aortic smooth muscle) and human THP-1 monocytic leukemia cells. Inhibition of cell proliferation by TPm was shown in both lines and occurred with TPm at concentrations lower than those at which a-tocopherol was equally inhibitory. TPm led in nonstimulated THP-1 cells to inhibition of CD36 mRNA and protein expression, to inhibition of oxidized low-density lipoprotein surface binding and oxLDL uptake. In nonstimulated THP-1 cells, α-tocopherol had only very weak effects on these events.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1031
DOIs
StatePublished - 2004
Externally publishedYes

Keywords

  • Di-α-tocopheryl phosphate
  • THP-1 cells
  • α-tocopheryl

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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