Abstract
A number of AraC family transcriptional activators bind low-molecular-weight ligands that modulate the activity of these proteins. Recently, it has become clear that the activity of several virulence-related AraC family members is regulated through the direct interaction of protein ligands. These interactions, in general, function to activate or repress the transcription of virulence genes in response to specific extracellular stimuli. The identification and characterization of several protein ligands that modify the activity of AraC family members in Pseudomonas aeruginosa and Salmonella enterica are discussed herein.
| Original language | English |
|---|---|
| Pages (from-to) | 287-290 |
| Number of pages | 4 |
| Journal | Molecular Microbiology |
| Volume | 54 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1 2004 |
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ASJC Scopus subject areas
- Molecular Biology
- Microbiology
Cite this
Modulation of AraC family member activity by protein ligands. / Plano, Gregory V.
In: Molecular Microbiology, Vol. 54, No. 2, 01.10.2004, p. 287-290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of AraC family member activity by protein ligands
AU - Plano, Gregory V
PY - 2004/10/1
Y1 - 2004/10/1
N2 - A number of AraC family transcriptional activators bind low-molecular-weight ligands that modulate the activity of these proteins. Recently, it has become clear that the activity of several virulence-related AraC family members is regulated through the direct interaction of protein ligands. These interactions, in general, function to activate or repress the transcription of virulence genes in response to specific extracellular stimuli. The identification and characterization of several protein ligands that modify the activity of AraC family members in Pseudomonas aeruginosa and Salmonella enterica are discussed herein.
AB - A number of AraC family transcriptional activators bind low-molecular-weight ligands that modulate the activity of these proteins. Recently, it has become clear that the activity of several virulence-related AraC family members is regulated through the direct interaction of protein ligands. These interactions, in general, function to activate or repress the transcription of virulence genes in response to specific extracellular stimuli. The identification and characterization of several protein ligands that modify the activity of AraC family members in Pseudomonas aeruginosa and Salmonella enterica are discussed herein.
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UR - http://www.scopus.com/inward/citedby.url?scp=6344275007&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2958.2004.04306.x
DO - 10.1111/j.1365-2958.2004.04306.x
M3 - Article
C2 - 15469502
AN - SCOPUS:6344275007
VL - 54
SP - 287
EP - 290
JO - Molecular Microbiology
JF - Molecular Microbiology
SN - 0950-382X
IS - 2
ER -