Modified recist (mRECIST) assessment for hepatocellular carcinoma

Riccardo Lencioni, Josep M. Llovet

Research output: Contribution to journalReview articlepeer-review

2008 Scopus citations

Abstract

The endpoint in cancer research is overall survival. Nonetheless, other potential surrogate endpoints, such as response rate and time to progression, are currently used. Measurement of response rate in hepatocellular carcinoma (HCC) has become a controversial issue. The World Health Organization (WHO) criteria underestimate the actual response rate; thus, they were amended in 2000 by a panel of experts convened by the European Association for the Study of the Liver (EASL) to take into account treatment-induced tumor necrosis. Applying these guidelines, there was an association between response rate and outcome prediction. More recently, the Response Evaluation Criteria in Solid Tumors (RECIST) guideline was proposed as a method for measuring treatment response based on tumor shrinkage, which is a valuable measure of antitumor activity of cytotoxic drugs. This method was initially adopted by regulatory agencies, such as the U.S. Food and Drug Administration (FDA), for drug approval. However, anatomic tumor response metrics can be misleading when applied to molecular-targeted therapies or locoregional therapies in HCC. In 2008, a group of experts convened by the American Association for the Study of Liver Diseases (AASLD) developed a set of guidelines aimed at providing a common framework for the design of clinical trials in HCC and adapted the concept of viable tumortumoral tissue showing uptake in arterial phase of contrast-enhanced radiologic imaging techniquesto formally amend RECIST. These amendments conformed the AASLD-JNCI (Journal of the National Cancer Institute) guidelines and are summarized and clarified in the current article. They are referred to herein as the modified RECIST assessment (mRECIST). Further studies are needed to confirm the accuracy of this measurement compared with conventional gold standards such as pathologic studies of explanted livers.

Original languageEnglish (US)
Pages (from-to)52-60
Number of pages9
JournalSeminars in liver disease
Volume30
Issue number1
DOIs
StatePublished - 2010

Keywords

  • AASLD-JNCI guidelines
  • Computed tomography
  • Hepatocellular carcinoma
  • Imaging
  • RECIST
  • Response assessment
  • Targeted therapies
  • Time to progression magnetic resonance

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Modified recist (mRECIST) assessment for hepatocellular carcinoma'. Together they form a unique fingerprint.

Cite this