Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: A case report

A. Frilling, H. Giele, G. Vrakas, S. Reddy, R. Macedo, A. Al-Nahhas, H. Wasan, A. K. Clift, G. E. Gondolesi, Rodrigo Vianna, P. Friend, A. Vaidya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonresectable, slow-growing tumors involving the mesenteric root represent a generally accepted indication for deceased donor intestinal and multivisceral transplantation. Furthermore, vascularized sentinel forearm flaps offer opportunities for monitoring graft rejection and tailoring immunosuppression regimens. Here, we report the first documented case of modified liver-free multivisceral transplantation preceded by neoadjuvant 177-lutetium peptide receptor radionuclide therapy in a patient with a small bowel neuroendocrine tumor and extensive lymph node metastases in the mesenterium. At a follow-up of 21 months the patient is biochemically and radiologically disease-free.

Original languageEnglish (US)
Pages (from-to)858-862
Number of pages5
JournalTransplantation Proceedings
Volume47
Issue number3
DOIs
StatePublished - Apr 1 2015

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Neuroendocrine Tumors
Transplantation
Liver
Lutetium
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Peptide Receptors
Graft Rejection
Forearm
Radioisotopes
Immunosuppression
Tissue Donors
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor : A case report. / Frilling, A.; Giele, H.; Vrakas, G.; Reddy, S.; Macedo, R.; Al-Nahhas, A.; Wasan, H.; Clift, A. K.; Gondolesi, G. E.; Vianna, Rodrigo; Friend, P.; Vaidya, A.

In: Transplantation Proceedings, Vol. 47, No. 3, 01.04.2015, p. 858-862.

Research output: Contribution to journalArticle

Frilling, A, Giele, H, Vrakas, G, Reddy, S, Macedo, R, Al-Nahhas, A, Wasan, H, Clift, AK, Gondolesi, GE, Vianna, R, Friend, P & Vaidya, A 2015, 'Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: A case report', Transplantation Proceedings, vol. 47, no. 3, pp. 858-862. https://doi.org/10.1016/j.transproceed.2015.01.007
Frilling, A. ; Giele, H. ; Vrakas, G. ; Reddy, S. ; Macedo, R. ; Al-Nahhas, A. ; Wasan, H. ; Clift, A. K. ; Gondolesi, G. E. ; Vianna, Rodrigo ; Friend, P. ; Vaidya, A. / Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor : A case report. In: Transplantation Proceedings. 2015 ; Vol. 47, No. 3. pp. 858-862.
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