Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect

Mamoru Shoji, Harold P. Morris, Craig W. Davis, Nancy Brackett, J. F. Kuo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Modifications in the cyclic nucleotide systems favoring the expression of cyclic GMP effects were found to occur in the transplanted fast-growing Morris hepatoma 3924A. These included: (a) a decreased level of cyclic GMP phosphodiesterase and an increased level of cyclic AMP phosphodiesterase; (b) a disproportionately increased level of cyclic GMP-dependent protein kinase relative to that of cyclic AMP-dependent protein kinase; (c) a disproportionately increased level of stimulatory modulator of cyclic GMP-dependent protein kinase relative to that of inhibitory modulator of cyclic AMP-dependent protein kinase; and (d) an increased level of phosphoprotein phosphatase.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalBBA - General Subjects
Volume500
Issue number2
DOIs
StatePublished - Dec 22 1977
Externally publishedYes

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Experimental Liver Neoplasms
Cyclic GMP-Dependent Protein Kinases
Cyclic Nucleotides
Cyclic GMP
Phosphoric Diester Hydrolases
Cyclic AMP-Dependent Protein Kinases
Modulators
Phosphoprotein Phosphatases
Cyclic AMP

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

Cite this

Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect. / Shoji, Mamoru; Morris, Harold P.; Davis, Craig W.; Brackett, Nancy; Kuo, J. F.

In: BBA - General Subjects, Vol. 500, No. 2, 22.12.1977, p. 419-424.

Research output: Contribution to journalArticle

Shoji, Mamoru ; Morris, Harold P. ; Davis, Craig W. ; Brackett, Nancy ; Kuo, J. F. / Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect. In: BBA - General Subjects. 1977 ; Vol. 500, No. 2. pp. 419-424.
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