Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect

Mamoru Shoji, Harold P. Morris, Craig W. Davis, Nancy L. Brackett, J. F. Kuo

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Modifications in the cyclic nucleotide systems favoring the expression of cyclic GMP effects were found to occur in the transplanted fast-growing Morris hepatoma 3924A. These included: (a) a decreased level of cyclic GMP phosphodiesterase and an increased level of cyclic AMP phosphodiesterase; (b) a disproportionately increased level of cyclic GMP-dependent protein kinase relative to that of cyclic AMP-dependent protein kinase; (c) a disproportionately increased level of stimulatory modulator of cyclic GMP-dependent protein kinase relative to that of inhibitory modulator of cyclic AMP-dependent protein kinase; and (d) an increased level of phosphoprotein phosphatase.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalBBA - General Subjects
Volume500
Issue number2
DOIs
StatePublished - Dec 22 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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