Modification of pentobarbital-induced sedation by natural and synthetic peptides

G. Bissette, C. B. Nemeroff, P. T. Loosen, G. R. Breese, G. B. Burnett, M. A. Lipton, A. J. Prange

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The effect of intraperitoneal (i.p.) and intracisternal (i.e.) injection of various endogenous peptides and related analogues on the sedation induced by a fixed intraperitoneal dose of sodium pentobarbital in mice was examined. Several peptides were found to antagonize the effects of pentobarbital while one (neurotensin) markedly potentiated them. Certain peptides were active only after intracisternal injection, while others were effective by either route of administration. However, peptides active after intraperitoneal administration were always active after intracisternal administration. Thyrotropin-releasing hormone was the most effective antagonist and was active by both routes. Neurotensin was the most potent potentiator but was active only after central administration. Although few general structural requirements for the analeptic activity of peptides are discernable, it appears that such activity is mediated by the central nervous system.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
Issue number4-5
StatePublished - 1978
Externally publishedYes


  • antagonism
  • pentobarbital sleeping time
  • peptides
  • potentiation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology


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