Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects

Arthur J. Prange, George R. Breese, Gloria D. Jahnke, Billy R. Martin, Barrett R. Cooper, Jerry M. Cott, Ian C. Wilson, Lacoe B. Alltop, Morris A. Lipton, Garth Bissette, Charles B. Nemeroff, Peter T. Loosen

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Thyrotropin releasing hormone (TRH) antagonizes pentobarbital sedation and hypothermia; somatotropin release inhibiting factor amplifies them. Other hypothalamic polypeptide releasing factors, Subtance P and a variety of amino acids are ineffective. Three congeners of TRH antagonize pentobarbital; one amplifies it. The potencies of congeners as pentobarbital antagonists are unrelated to their potencies as pituitary thyrotropin releasers.

Original languageEnglish (US)
Pages (from-to)1907-1913
Number of pages7
JournalUnknown Journal
Volume16
Issue number12
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Prange, A. J., Breese, G. R., Jahnke, G. D., Martin, B. R., Cooper, B. R., Cott, J. M., Wilson, I. C., Alltop, L. B., Lipton, M. A., Bissette, G., Nemeroff, C. B., & Loosen, P. T. (1975). Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects. Unknown Journal, 16(12), 1907-1913. https://doi.org/10.1016/0024-3205(75)90284-2