Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects

A. J. Prange, G. R. Breese, G. D. Jahnke, B. R. Martin, B. T. Cooper, J. M. Cott, I. C. Wilson, L. B. Alltop, M. A. Lipton, G. Bissette, Charles Nemeroff, P. T. Loosen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Thyrotropin releasing hormone (TRH) antagonizes pentobarbital sedation and hypothermia; somatotropin release inhibiting factor amplifies them. Other hypothalamic polypeptide releasing factors, Subtance P and a variety of amino acids are ineffective. Three congeners of TRH antagonize pentobarbital; one amplifies it. The potencies of congeners as pentobarbital antagonists are unrelated to their potencies as pituitary thyrotropin releasers.

Original languageEnglish
Pages (from-to)1907-1914
Number of pages8
JournalLife Sciences
Volume16
Issue number12
DOIs
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Pentobarbital
Brain
Thyrotropin-Releasing Hormone
Peptides
Hypothermia
Pituitary Hormone-Releasing Hormones
Thyrotropin
Somatostatin
Amino Acids

ASJC Scopus subject areas

  • Pharmacology

Cite this

Prange, A. J., Breese, G. R., Jahnke, G. D., Martin, B. R., Cooper, B. T., Cott, J. M., ... Loosen, P. T. (1975). Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects. Life Sciences, 16(12), 1907-1914. https://doi.org/10.1016/0024-3205(75)90284-2

Modification of pentobarbital effects by natural and synthetic polypeptides : dissociation of brain and pituitary effects. / Prange, A. J.; Breese, G. R.; Jahnke, G. D.; Martin, B. R.; Cooper, B. T.; Cott, J. M.; Wilson, I. C.; Alltop, L. B.; Lipton, M. A.; Bissette, G.; Nemeroff, Charles; Loosen, P. T.

In: Life Sciences, Vol. 16, No. 12, 01.12.1975, p. 1907-1914.

Research output: Contribution to journalArticle

Prange, AJ, Breese, GR, Jahnke, GD, Martin, BR, Cooper, BT, Cott, JM, Wilson, IC, Alltop, LB, Lipton, MA, Bissette, G, Nemeroff, C & Loosen, PT 1975, 'Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects', Life Sciences, vol. 16, no. 12, pp. 1907-1914. https://doi.org/10.1016/0024-3205(75)90284-2
Prange, A. J. ; Breese, G. R. ; Jahnke, G. D. ; Martin, B. R. ; Cooper, B. T. ; Cott, J. M. ; Wilson, I. C. ; Alltop, L. B. ; Lipton, M. A. ; Bissette, G. ; Nemeroff, Charles ; Loosen, P. T. / Modification of pentobarbital effects by natural and synthetic polypeptides : dissociation of brain and pituitary effects. In: Life Sciences. 1975 ; Vol. 16, No. 12. pp. 1907-1914.
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