Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects

Arthur J. Prange; George R. Breese; Gloria D. Jahnke; Billy R. Martin; Barrett R. Cooper; Jerry M. Cott; Ian C. Wilson; Lacoe B. Alltop; Morris A. Lipton; Garth Bissette; Charles B. Nemeroff; Peter T. Loosen

doi:10.1016/0024-3205(75)90284-2

Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects

Arthur J. Prange, George R. Breese, Gloria D. Jahnke, Billy R. Martin, Barrett R. Cooper, Jerry M. Cott, Ian C. Wilson, Lacoe B. Alltop, Morris A. Lipton, Garth Bissette, Charles B. Nemeroff, Peter T. Loosen

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

Thyrotropin releasing hormone (TRH) antagonizes pentobarbital sedation and hypothermia; somatotropin release inhibiting factor amplifies them. Other hypothalamic polypeptide releasing factors, Subtance P and a variety of amino acids are ineffective. Three congeners of TRH antagonize pentobarbital; one amplifies it. The potencies of congeners as pentobarbital antagonists are unrelated to their potencies as pituitary thyrotropin releasers.

Original language	English (US)
Pages (from-to)	1907-1913
Number of pages	7
Journal	Unknown Journal
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(75)90284-2
State	Published - Jan 1 1975
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(75)90284-2

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Prange, A. J., Breese, G. R., Jahnke, G. D., Martin, B. R., Cooper, B. R., Cott, J. M., Wilson, I. C., Alltop, L. B., Lipton, M. A., Bissette, G., Nemeroff, C. B., & Loosen, P. T. (1975). Modification of pentobarbital effects by natural and synthetic polypeptides: dissociation of brain and pituitary effects. Unknown Journal, 16(12), 1907-1913. https://doi.org/10.1016/0024-3205(75)90284-2

Modification of pentobarbital effects by natural and synthetic polypeptides : dissociation of brain and pituitary effects. / Prange, Arthur J.; Breese, George R.; Jahnke, Gloria D.; Martin, Billy R.; Cooper, Barrett R.; Cott, Jerry M.; Wilson, Ian C.; Alltop, Lacoe B.; Lipton, Morris A.; Bissette, Garth; Nemeroff, Charles B.; Loosen, Peter T.

In: Unknown Journal, Vol. 16, No. 12, 01.01.1975, p. 1907-1913.

Research output: Contribution to journal › Article

Prange, Arthur J. ; Breese, George R. ; Jahnke, Gloria D. ; Martin, Billy R. ; Cooper, Barrett R. ; Cott, Jerry M. ; Wilson, Ian C. ; Alltop, Lacoe B. ; Lipton, Morris A. ; Bissette, Garth ; Nemeroff, Charles B. ; Loosen, Peter T. / Modification of pentobarbital effects by natural and synthetic polypeptides : dissociation of brain and pituitary effects. In: Unknown Journal. 1975 ; Vol. 16, No. 12. pp. 1907-1913.

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abstract = "Thyrotropin releasing hormone (TRH) antagonizes pentobarbital sedation and hypothermia; somatotropin release inhibiting factor amplifies them. Other hypothalamic polypeptide releasing factors, Subtance P and a variety of amino acids are ineffective. Three congeners of TRH antagonize pentobarbital; one amplifies it. The potencies of congeners as pentobarbital antagonists are unrelated to their potencies as pituitary thyrotropin releasers.",

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