Modification of glycogen deposition by priming glucose loads: The second-meal phenomenon

C. Abraira, B. Buchanan, L. Hodges

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Glucose priming modifies tolerance and oxidation of subsequent loads. To assess effects in glycogenesis, rats were given a D-[U14C]-glucose load, either alone or preceded by one or two unlabeled hourly doses. The incorporation of 14C into total liver glycogen was 8.6 ± 0.4% of the glucose dose and was little changed by priming loads. Total liver glycogen was 169 ± 10 mg after one load and 276 ± 12 mg after two; after three it fell to 243 ± 20 mg. In muscle, net incorporation of 14C was 9.6 ± 0.6% of the first but fell to 6.9 ± 0.4% of the third glucose 14C dose/100 g. Muscle glycogen concentration rose at a decremental rate with priming. Net incorporation of glucose 14C into hepatic glycogen remains constant after repeated loads even after storage is reduced. In keeping with the reported peripheral resistance to glucose uptake in the second-meal phenomenon, repeated loading is associated with reduction of 14C-glucose incorporation into muscle glycogen.

Original languageEnglish
Pages (from-to)952-957
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume45
Issue number5
StatePublished - Jan 1 1987

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Glycogen
glycogen
Meals
Glucose
glucose
Liver Glycogen
Muscles
muscles
liver
dosage
glycogenesis
Vascular Resistance
Rosa
oxidation
rats

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Modification of glycogen deposition by priming glucose loads : The second-meal phenomenon. / Abraira, C.; Buchanan, B.; Hodges, L.

In: American Journal of Clinical Nutrition, Vol. 45, No. 5, 01.01.1987, p. 952-957.

Research output: Contribution to journalArticle

Abraira, C. ; Buchanan, B. ; Hodges, L. / Modification of glycogen deposition by priming glucose loads : The second-meal phenomenon. In: American Journal of Clinical Nutrition. 1987 ; Vol. 45, No. 5. pp. 952-957.
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